Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines |
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| Authors: | Ohashi Emi Inoue Kaori Kagechika Hiroyuki Hong Sung-Hyeok NakagawaTakayuki Takahashi Tomoko Mochizuki Manabu Nishimura Ryouhei Sasaki Nobuo |
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| Institution: | Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan. |
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| Abstract: | The effect of two natural retinoids and synthetic retinoids with or without retinoid synergists on the proliferation and differentiation of 3 melanoma cell lines were investigated in vitro. No retinoids showed significant growth inhibitory effect on these cell lines when used alone, however, cell differentiation and significant growth inhibition were observed when treated with a combination of retinoids and a retinoid synergist. This study may suggest that, though the cells showed low susceptibilities when retinoids were treated alone, the combination of retinoids and a retinoid synergist may be effective to control the growth of canine melanoma cell lines. |
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