Inhibition of Vibrio spp. by 2‐Hydroxyethyl‐11‐hydroxyhexadec‐9‐enoate of Marine Cyanobacterium Leptolyngbya sp. LT19 |
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| Authors: | Nipat Maneechote Boon‐ek Yingyongnarongkul Apichart Suksamran Saisamorn Lumyong |
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| Institution: | 1. Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand;2. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhang University, Bankok, Thailand |
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| Abstract: | Seven marine cyanobacteria were isolated from two regions of the Gulf of Thailand and evaluated by the agar diffusion method for antibacterial activity. Inhibitory compound was purified from the crude methanol extract and its structure was elucidated based on extensive spectroscopic analysis, including IR, 1D and 2D NMR spectra as well as mass spectrometry. A novel antimicrobial compound produced by the marine cyanobacterium Leptolyngbya sp. LT19 was identified to be a 2‐hydroxyethyl‐11‐hydroxyhexadec‐9‐enoate which has so far never been reported in microorganisms. Biological assays revealed that this novel compound exhibited antibacterial activities against the Gram‐negative, persistent shrimp pathogens, Vibrio harveyi and V. parahaemolyticus with minimal inhibitory concentration of 250–1000 and 350–1000 μg mL?1 respectively. |
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| Keywords: | marine cyanobacterium
Vibrio harveyi
Vibrio parahaemolyticus
unsaturated fatty acid
NMR
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