Plasma concentration of sulphadimethoxine in pigs after multiple dosing and during injections of Escherichia coli endotoxin |
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| Authors: | O Ladefoged |
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| Institution: | (1) Department of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, 1870 Copenhagen V, (Denmark) |
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| Abstract: | The effect of endotoxin induced fever on the  steady state concentration of sulphadimethoxine in pigs has been studied.Sulphadimethoxine 20 mg/kg b.wt. was injected at 9 a.m. in an ear vein each day for eleven days. From day 6 until the end of the experiment, endotoxin fromEscherichia coli 1.5  g/kg b.wt. was injected at 9 a.m. and at 3 p.m. The plasma concentration versus time curves were calculated by means of a computer program, assuming a two-compartment model. During the endotoxin injections the plasma concentrations were simulated and compared with those calculated.It was not possible to show any clinically significant changes in pharmacokinetics of sulphadimethoxine after the start of endotoxin injections. |
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