| 病原菌自转运黏附素(Autotransporter adhesin)的研究进展 |
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| 引用本文： | 韩文瑜,谢芳,雷连成.病原菌自转运黏附素(Autotransporter adhesin)的研究进展[J].中国兽医学报,2010,30(4). |
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| 作者姓名： | 韩文瑜 谢芳 雷连成 |
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| 作者单位： | 吉林大学,畜牧兽医学院,吉林,长春,130062 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 病原菌对宿主细胞的黏附是引发感染的第一步.分泌到革兰氏阴性菌表面的自转运黏附素调节着细菌对宿主细胞的黏附,是重要的毒力因子.本文综述了自转运黏附素的结构和功能特征.并且评价了自转运黏附素用于疫苗的潜力,有望为研制防御革兰氏阴性菌感染疫苗提供新的设计靶位.
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| 关 键 词： | 自转运蛋白 黏附素 V型分泌系统 生物被膜 革兰氏阴性菌 |
Progress on autotransporter adhesins of pathogens |
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| HAN Wen-yu,XIE Fang,LEI Lian-cheng.Progress on autotransporter adhesins of pathogens[J].Chinese Journal of Veterinary Science,2010,30(4). |
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| Authors: | HAN Wen-yu XIE Fang LEI Lian-cheng |
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| Abstract: | An ability of bacterial proteins to promote adhesion to biological surfaces is a fundamental step in bacterial infections.Autotransporter adhesion,which is secreted to the surface of Gram-negative bacteria,is important viru-lence factors and mediates adherence to eukaryotic cells.In this article,we review our current knowledge of the struc-tural and functional characteristics of autotransporter adhesion,highlighting a potential of autotransporter adhesion as targets for the design of novel vaccines directed against Gram-negative pathogens. |
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| Keywords: | autotransporter protein adhesion type V secretion biofilm Gram-negative bacteria |
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