Effect of atorvastatin on progression of heart failure and association with sodium-calcium exchanger expression |
| |
| Authors: | WANG Shu WANG Rui JIANG Ya-nan WANG Lan-feng PAN Wei TIAN Ye |
| |
| Institution: | 1.Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin 150006, China;2.Heilongjiang Nursing College, Harbin Medical University, Harbin 150006, China;3.Department of Pharmacology, Harbin Medical University, Harbin 150006, China |
| |
| Abstract: | AIM: To investigate the effect of atorvastatin on the development of heart failure after myocardial infarction and the association with sodium-calcium exchanger (NCX) expression.METHODS: The model of heart failure was established by ligation of the anterior descending coronary artery for 8 weeks. The rats were randomly divided into control group, heart failure group, and atorvastatin group. Either atorvastatin (10 mg·kg-1·d-1) or vehicle was orally administered to the rats on the next day after the surgery. The left ventricular function and NCX expression were analyzed 8 weeks after ligation. Neonatal rat cardiomyocytes were cultured to investigate the effect of atorvastatin on the changes of calcium concentration induced by hypoxemia.RESULTS: A decrease in left ventricular diastolic dimension, an increase in left ventricular fractional shortening, and reductions of BNP level and NCX expression were observed in atorvastatin group. The hypoxemia-induced calcium overload in cultured cardiomyocytes was inhibited by atorvastatin, and it was inhibited by the inhibitor of NCX.CONCLUSION: Atorvastatin treatment improves cardiac function, which may be related to the expression and function of sodium calcium exchanger in heart failure. |
| |
| Keywords: | Sodium-calcium exchanger Heart failure Atorvastatin |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|
