Analysis on Target Genes with Mutation in microRNA of Blue-shelled Chicken and White Leghorn |
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| Authors: | GUAN Yu-yu LIAO Rong-rong WANG Zhen ZHAO Jing CHEN Zhen-liang ZHANG Zhe XIAO Qian SUN Hao WANG Qi-shan ZHANG Xiang-zhe YANG Chang-suo PAN Yu-chun |
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| Institution: | 1. School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China;2. Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai 200240, China;3. Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China |
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| Abstract: | The study was conducted to explore the potential different characters between Blue-shelled chicken and White leghorn.Global genome microRNA was combined the identified microRNA with complementary lab-predicted microRNA.Then the two breed chicken's SNP data got by GGRS were mapped to the microRNA and focused on SNP that deliberately located in mature-microRNA.Bioinformatics method was adopted for target prediction on microRNA which had SNPs.By further gene enrichment analysis,the study found these genes enriched in 22 GO terms,10 KEGG pathways,and 3 IPA important networks.And they enriched in traits which associated with growth,such as mTOR signaling pathways,Wnt signaling pathways,growth hormone receptor networks and insulin-like growth factor Ⅰ receptor networks.And they also enriched in some laying traits,such as oocyte meiotic signaling pathways and progesterone mature oocytes signaling pathways.The methods and the results might provide references for further studies. |
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| Keywords: | Blue-shelled chicken White leghorn microRNA SNP target genes prediction enrichment analysis |
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