Research Progress on Biofilms in Pseudomonas aeruginosa |
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| Authors: | MENG Fei LI Shu-chang YANG Wu-ning LIU Wei YIN Hui-hui WEI Xiao-jie JIANG Yuan-ming ZHAO Wu QIN Zhen-hua SUN Jian-hua |
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| Institution: | 1. Guangxi Key Laboratory of Animal Epidemic Etiology and Diagnostic, Guangxi Veterinary Research Institute, Nanning 530001, China;
2. College of Animal Science and Technology, Guangxi University, Nanning 530004, China;
3. Institute of Veterinary Drug Control of Guangxi Zhuang Autonomous Region, Nanning 530001, China |
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| Abstract: | The opportunistic pathogen Pseudomonas aeruginosa is a gram-negative bacteria which can form biofilms.In this review,we summarized the biology mechanism of biofilms in Pseudomonas aeruginosa,including Pseudomonas aeruginosa adhesion,extracellular polysaccharide Psl and Pel,alginate participated in the biofilm maturation,and quorum sensing systems regulated the formation of biofilm in Pseudomonas aeruginosa,and the drug target on biofilm.The bacterial biofilms protected the bacteria from unsuitable environmental conditions.Through researching the structure and the pathogenesis of Pseudomonas aeruginosa,and its resistance molecular mechanisms,we could adjust or regulate the expression of biofilm-associated factors,optimize the anti-infection treatment in Pseudomonas aeruginosa. |
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| Keywords: | Pseudomonas aeruginosa biofilms quoring sensing system |
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