Effect of Taurochenodeoxycholic Acid on the Proliferation of the Mouse Macrophage Cell Line RAW264.7 |
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| Authors: | ZHANG Wen WANG Jian-guang LI Jin-lian ZHAO Xiao-min CHEN Zheng-tao ZHOU Chuan SHI You-fei |
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| Institution: | 1. College of Animal Science, Shandong Agricultural University, Tai'an 271018, China;
2. Xilingol Vocationol College, Xilinhaote 026000, China;
3. Department of Biological Science and Technology, Taishan University, Tai'an 271021, China;
4. Institute of Immunology, Taishan Medical University, Tai'an 271018, China |
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| Abstract: | We carried out the research of the effect of taurochenodeoxycholic acid (TCDCA) on the apoptosis of the mouse macrophage cell line RAW264.7 and expression of IAPs including CIAP-1,CIAP-2 and XIAP.The results showed that TCDCA with the dose of 0.05,0.10 and 10 μg/mL could extremely significantly prevent cells apoptosis that were induced by DEX (P < 0.01).TCDCA with the dose of 1 μg/mL could significantly promote mRNA expressions of CIAP-1 and XIAP (P < 0.05),while the dose of 10 μg/mL could significantly promote mRNA expressions of CIAP-1,CIAP-2 and XIAP (P < 0.05),TCDCA could also extremely significantly up-regulate the expression of CIAP-1,CIAP-2 and XIAP (P < 0.01) in RAW264.7 cell line by DEX,but this depended on different doses of TCDCA.The above research results showed that TCDCA could resist the cells apoptosis of the mouse macrophage cell line RAW264.7 that were induced by DEX,which was related with the influence on the mRNA expression of IAPs. |
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| Keywords: | taurochenodeoxycholic acid mouse macrophage cell line RAW264 7 cell apoptosis IAPs |
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