| 乙型肝炎失代偿期肝硬化患者血清内毒素、 IL-12、IL-18水平的检测及其意义 |
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| 引用本文： | 曾宏.乙型肝炎失代偿期肝硬化患者血清内毒素、 IL-12、IL-18水平的检测及其意义[J].湛江医学院学报,2005,23(3):264-265. |
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| 作者姓名： | 曾宏 |
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| 作者单位： | 广东省惠州市中心人民医院,广东,惠州,516001 |
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| 摘 要： | 目的探讨乙型肝炎肝硬化血清内毒素(LPS)、白介素-12(IL-12)、白介素-18(IL-18)水平变化及临床意义.方法采用鲎试剂(Ⅱ)-偶氮显色法、ELISA双抗体夹心法,分别测定80例肝硬化患者血清LPS、IL-12、IL-18水平.另设正常对照组(32例).结果与正常对照组比较,肝硬化患者血清LPS、IL-12、IL-18水平均明显升高,且随着肝功能越差,升高越明显(P＜0.01);腹水组的LPS及IL-12、IL-18水平较无腹水组也明显增高(P＜0.01).结论LPS、IL-12、IL-18均参与了乙型肝炎肝硬化的病理生理过程,并与病情的变化密切相关.检测这些指标有助于判断肝硬化患者的肝功能状况及疾病的严重程度.
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| 关 键 词： | 内毒素 IL-12 IL-18 肝硬化 |
| 文章编号： | 1005-4057(2005)03-0264-02 |
| 修稿时间： | 2005年1月18日 |
Serum levels of endotoxin, IL-12 and IL-18 in patients with type B hepatitis-related decompensate cirrhosis |
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| ZENG Hong.Serum levels of endotoxin, IL-12 and IL-18 in patients with type B hepatitis-related decompensate cirrhosis[J].Journal of Guangdong Medical College,2005,23(3):264-265. |
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| Authors: | ZENG Hong |
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| Abstract: | Objective: To observe the changes of endotoxin, IL-12 and IL-18 levels in patients with type B hepatitis-related cirrhosis. Methods: Endotoxin, IL-12 and IL-18 contents in 80 patients with type B hepatitis-related cirrhosis and 32 normal controls were determined by limulus test and ELISA, respectively. Results: The levels of endotoxin, IL-12 and IL-18 were significantly higher in cirrhosis group than those in control group, especially in patients with decompensate cirrhosis (P<0.01). Conclusion: Endotoxin, IL-12 and IL-18 are involved in the pathophysiology of type B hepatitis-related cirrhosis, and their detection is helpful in judging the disease severity. |
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| Keywords: | endotoxin IL-12 IL-18 hepatic cirrhosis |
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