| 安吉白茶多糖抗肿瘤及免疫调节研究 |
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| 引用本文： | 夏道宗,张元君,倪达美,居梦婷.安吉白茶多糖抗肿瘤及免疫调节研究[J].茶叶科学,2013(1):40-44. |
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| 作者姓名： | 夏道宗 张元君 倪达美 居梦婷 |
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| 作者单位： | 浙江中医药大学药学院食品教研室,浙江 杭州 310053 |
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| 基金项目： | 国家自然科学基金(No.81102861);浙江省自然科学基金(No.Y2110031);浙江省博士后科研项目择优资助(No.2011[368]) |
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| 摘 要： | 选用MTT法研究了安吉白茶多糖的体外抗肿瘤活性;采用建立小鼠移植瘤模型,通过测定安吉白茶多糖对荷瘤小鼠抑瘤率和腹腔巨噬细胞吞噬能力,研究其体内抗肿瘤活性和免疫调节作用。结果表明,安吉白茶多糖体外能显著抑制S180细胞的生长,且具有剂量依赖关系。体内试验表明,与模型对照组相比,安吉白茶多糖对小鼠S180实体瘤和H22腹水型肝癌移植瘤的生长均有显著抑制作用(P<0.05),对荷瘤小鼠脾指数和胸腺指数也有较强增高作用。体内免疫调节试验结果显示,安吉白茶多糖可使荷S180实体瘤小鼠腹腔巨噬细胞吞噬能力显著升高(P<0.05)。
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| 关 键 词： | 安吉白茶多糖 抗肿瘤 免疫调节 腹腔巨噬细胞 吞噬能力 |
Study on Antitumor and Immune Regulation Activities of Anjibaicha Polysaccharide |
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| XIA Dao-zong,ZHANG Yuan-jun,NI Da-mei,JU Meng-ting.Study on Antitumor and Immune Regulation Activities of Anjibaicha Polysaccharide[J].Journal of Tea Science,2013(1):40-44. |
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| Authors: | XIA Dao-zong ZHANG Yuan-jun NI Da-mei JU Meng-ting |
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| Institution: | Department of Food Sciences,College of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China |
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| Abstract: | The antitumor activity of anjibaicha polysaccharide in vitro by MTT method was investigated by the authors.For the purpose of investigating the antitumor and immune regulation functions of anjibaicha polysaccharide in vivo,to establish the transplant tumor model of mice,and determine the inhibition rate on tumor cells growth and peritoneal macrophage phagocytic function of tumor-burdened mice by anjibaicha polysaccharide.The results showed that the sarcoma-180 growth could be significant inhibited by anjibaicha polysaccharide in vitro and showed dose-dependent relation ship.The test in vivo showed that anjibaicha polysaccharide has significant inhibitory effects on sarcoma-180 and ascitic hepatoma H22 growth in tumor-burdened mice(P< 0.05).In addition,anjibaicha polysaccharide could increase thymus and spleen indexs in mice with sarcoma-180 and ascitic hepatoma H22 cells.Moreover,anjibaicha polysaccharide could significantly increase the peritoneal macrophage phagocytic function in sarcoma-180-burdened mice(P<0.05). |
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| Keywords: | anjibaicha polysaccharide antitumor immune regulation peritoneal macrophage phagocytic function |
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