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| 司帕沙星在实验性感染大肠杆菌-败血霉形体病鸡体内的组织动力学及残留研究 | |
| 引用本文： | 刘明春,吕秋凤,陈彬,佟恒敏,赵玉军.司帕沙星在实验性感染大肠杆菌-败血霉形体病鸡体内的组织动力学及残留研究[J].东北农业大学学报,2006,37(5):646-649. |
| 作者姓名： | 刘明春 吕秋凤 陈彬 佟恒敏 赵玉军 |
| 作者单位： | 1. 沈阳农业大学畜牧兽医学院,辽宁,沈阳,110161 2. 沈阳农业大学分析测试中心,辽宁,沈阳,110161 3. 东北农业大学动物医学院,黑龙江,哈尔滨,150030 |
| 基金项目： | 辽宁省博士科研项目，辽宁省教育厅资助项目 |
| 摘 要： | 实验性感染大肠杆菌—败血霉形体病鸡,单剂量(5 mg.kg-1)内服司帕沙星,研究其组织动力学和残留情况。采用HPLC面积-内标法测定各组织中司帕沙星浓度,利用药动学分析软件MCPKP分析药-时数据。疾病模型鸡肝脏、肺脏和心脏中的药—时数据符合一级吸收三项指数方程,主要动力学参数为:t1/2α0.3505,0.8381,0.6005 h;t1/2β11.7802,13.8479,2.4578 h;tmax 1.0653,1.1397,0.7546 h;Cmax 3.3591,2.2951,1.7226μg.mL-1;AUC24.4230,30.663,5.3780 mg.L-1.h-1,Tcp(ther)81.0240,108.52,18.410 h。肾脏和肌肉组织中药-时数据符合一级吸收二项指数方程,主要动力学参数为:t1/2K 2.2287,7.5072 h;tmax1.4655,1.8644 h;Cmax1.9926,1.1317μg.mL-1;AUC9.8536,14.5240 mg.L-1.h-1;Tcp(ther)19.923,58.156 h。各组织中药物浓度降至0.001 mg.kg-1时需休药7 d。 |
| 关 键 词： | 司帕沙星 大肠杆菌-败血霉形体感染鸡 组织动力学 残留 |
| 文章编号： | 1005-9369（2006）05-0646-04 |
| 收稿时间： | 2005-10-25 |
| 修稿时间： | 2005年10月25 |
Tissues pharmacokinetics and residues of sparfloxacin in experimentally induced E.coli-Mycoplasma gallisepticu disease chickens |
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| LIU Mingchun,LV Qiufeng,CHEN Bin,TONG Hengmin,ZHAO Yujun.Tissues pharmacokinetics and residues of sparfloxacin in experimentally induced E.coli-Mycoplasma gallisepticu disease chickens[J].Journal of Northeast Agricultural University,2006,37(5):646-649. | |
| Authors: | LIU Mingchun LV Qiufeng CHEN Bin TONG Hengmin ZHAO Yujun |
| Abstract: | A single dose(5 mg·kg-1) of sparfloxacin was oral administered to experimentally induced E.coli-MG chickens.The drug concentrations in tissues were detected by HPLC and the pharmacokinetics parameters were analyzed with MCPKP.The results showed that the liver,lung and heart concentration-time curves after oral administration were best described by a tri-exponential equation with the first order absorption.The main pharmacokinetic parameters were as follows: t1/2α0.3505,0.8381,0.6005 h;t1/2β 11.7802,13.8479,2.4578 h;tmax 1.0653,1.1397,0.7546 h;Cmax 3.3591,2.2951,1.7226 g·mL-1;AUC 22.4230,30.6630,5.3780 mg·L-1·h-1;Tcp(ther) 81.024,108.52 h respectively.The kidney and muscle concentration-time data fitted the bi-exponential equation with first order absorption.Their main pharmacokinetic parameters were: t1/2k 2.2287,7.5075 h,tmax 1.4655,1.8644 h,Cmax 1.9926,1.1317 μg·mL-1;AUC9.8536,14.5240 mg·L-1·h-1.Tcp(ther) 19.923,58.156 h respectively.The withdrawal time of sparfloxacin concentrations in tissues reduce to 0.001 μg·mL-1 were suggested as 7 days. |
| Keywords: | sparfloxacin Escherichia coli -Mycoplasma gallisepticu disease chickens pharmacokinetics residues |
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