| 氟苯尼考单剂量腹腔注射和灌服后在鲫体内的药代动力学 |
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| 引用本文： | 刘海侠,刘晓强,张振龙,李远鹏.氟苯尼考单剂量腹腔注射和灌服后在鲫体内的药代动力学[J].西北农业学报,2011,20(5):54-58. |
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| 作者姓名： | 刘海侠 刘晓强 张振龙 李远鹏 |
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| 作者单位： | 1. 西北农林科技大学动物科技学院,陕西杨凌,712100
2. 西北农林科技大学动物医学院,陕西杨凌,712100 |
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| 基金项目： | 西北农林科技大学校级教学研究项目 |
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| 摘 要： | 将健康鲫150尾随机分成两组,按30mg.kg-1剂量分别单次腹腔注射和灌服氟苯尼考,用高效液相色谱法研究其在鲫体内的药代动力学特征,数据用3p97药代动力学软件分析。结果表明,腹腔液射和灌服两种给药方式的血药经时过程均符合一级吸收一室开放模型。腹腔注射和灌服给药的动力学方程分别为ρ=3.465 5(e-0.51t-e-14.88t)和ρ=7.669 9(e-0.04t-e-0.12t)。药时曲线下面积(AUC)分别为(3.905±0.056)和(1.803±0.133)mg.L-1.h;分布速率半衰期(t1/2Ka)分别为(0.047±0.001)和(5.962±0.021)h,消除速率半衰期(t1/2Ke)分别为(1.367±0.025)和(16.763±0.017)h,体清除率(CLB)分别为(0.102±0.001)和(0.018±0.017)L.kg-1.h-1,最高血药质量浓度(ρmax)分别为(25.289±2.664)和(42.137±3.887)mg.L-1。
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| 关 键 词： | 氟苯尼考 鲫 药代动力学 |
Pharmacokinetics of Florfenicol Induced through Single Enterocoelia Injection and Oral Administration to Carassius auratus |
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| LIU Haixi,LIU Xiaoqiang,ZHANG Zhenlong and LI Yuanpeng.Pharmacokinetics of Florfenicol Induced through Single Enterocoelia Injection and Oral Administration to Carassius auratus[J].Acta Agriculturae Boreali-occidentalis Sinica,2011,20(5):54-58. |
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| Authors: | LIU Haixi LIU Xiaoqiang ZHANG Zhenlong and LI Yuanpeng |
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| Institution: | LIU Haixia1,LIU Xiaoqiang2,ZHANG Zhenlong1 and LI Yuanpeng1(1.College of Animal Science,Northwest A&F University,Yangling Shaanxi 712100,China,2.College of Veterinary Medicine,China) |
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| Abstract: | 150 healthy Carassius auratus were allocated into two groups randomly.The pharmaco-kinetics of florfenicol in body of Carassius auratus introduced through single enterocoelia injection and oral administration by a dose of 30 mg·kg-1were studied by HPL,respectively.Pharmacokinetics parameters were calculated by 3p97 software.Concentration-time data relating to the two groups were best described by a one-compartment open model,ρ=3.465 5(e-0.51t-e-14.88t) for single enterocoelia injection and ρ=7.669 9(e-0.04t-e-0.12 t) for oral administration.The important parameters in the models of enterocoelia injection injection and oral administration were that AUC were discriminately(3.905±0.056)mg·L-1·h and(1.803±0.133) mg·L-1·h;the distribution half lives(t1/2Ka) were(0.047±0.001) and(5.962±0.021) h;the elimination half lives(t1/2Ke) were(1.367±0.025) and(16.763±0.017) h;the total body clearance(CLB) were(0.102±0.001) and(0.018±0.017) L·kg-1·h-1;the peak plasma concentrations(ρmax) were(25.289±2.664) and(42.137±3.887) mg·L-1,respectively. |
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| Keywords: | Florfenicol Carassius auratus Pharmacokinetics |
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