| 机体识别病毒核酸的几种分子模式及途径 |
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| 引用本文： | 景志忠,何小兵,房永祥,陈国华,曾爽,贾怀杰.机体识别病毒核酸的几种分子模式及途径[J].畜牧兽医学报,2011,42(3). |
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| 作者姓名： | 景志忠 何小兵 房永祥 陈国华 曾爽 贾怀杰 |
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| 作者单位： | 中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,农业部兽医公共卫生,重点实验室,兰州,730046 |
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| 基金项目： | 国家自然科学基金项目(30871884); 转基因生物新品种培育重大专项(2009ZX08008-010B) |
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| 摘 要： | 近些年机体病原相关模式受体及其识别分子机制的研究,极大地促进了先天性分子免疫学的发展,并成为现代免疫学研究的重点和热点领域。作者通过机体识别病毒核酸的Toll样受体(Toll-like receptors,TLRs)、RIG-I样受体(RIG-I like receptors,RLRs)、NOD样受体(NOD-like receptors,NLRs)和DAI(DNA-dependent activatorof interferon-regulatory factors,DAI)等模式识别分子的细胞定位、分子结构及其识别病毒核酸途径的介绍,系统、全面地探讨了宿主机体如何全方位识别和消除入侵病毒的分子免疫防御途径,为抗病毒药物和疫苗的设计以及抗病育种提供了理论依据。
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| 关 键 词： | 病原相关分子模式 模式识别受体 病毒核酸 先天性免疫 |
Progress on the Molecular Patterns and Pathways of Host Recognition to Viral Nucleic Acids |
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| JING Zhi-zhong,HE Xiao-bing,FANG Yong-xiang,CHEN Guo-hua,ZENG Shuang,JIA Huai-jie.Progress on the Molecular Patterns and Pathways of Host Recognition to Viral Nucleic Acids[J].Acta Veterinaria et Zootechnica Sinica,2011,42(3). |
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| Authors: | JING Zhi-zhong HE Xiao-bing FANG Yong-xiang CHEN Guo-hua ZENG Shuang JIA Huai-jie |
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| Institution: | JING Zhi-zhong,HE Xiao-bing,FANG Yong-xiang,CHEN Guo-hua,ZENG Shuang,JIA Huai-jie (Key Laboratory of Veterinary Public Health of Agricultural Ministry,State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China) |
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| Abstract: | Molecular mechanism of pathogen recognition by the host innate immune system has become an exciting and growing area of research focus in recent years.It also promotes the development of innate molecular immunology.This review mainly introduces the cellular localization,molecular construction and interaction pathway of the multiple pattern recognition receptor(PRR) families,including Toll-like receptors(TLRs),RIG-I-like receptors(RLRs),NOD-like receptors(NLRs) and DNA-dependent activator of interferon-regul... |
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| Keywords: | pathogen-associated molecular patterns(PAMPs) pattern recognition receptors(PRRs) viral nucleic acids innate immunity |
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