| “信息园艺学论坛”在成都举行 |
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| 引用本文： | 无.“信息园艺学论坛”在成都举行[J].园艺学报,2007,34(3):574-578. |
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| 作者姓名： | 无 |
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| 作者单位： | [1]《园艺学报》编辑部 [2]中国农业科学院蔬菜花卉研究所生物技术研究室 |
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| 摘 要： | 由《园艺学报》编辑部和中国农业科学院蔬菜花卉研究所生物技术研究室共同发起和主办的“信息园艺学论坛”于2007年5月28～29日在成都举行。
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| 关 键 词： | 园艺学 中国农业科学院蔬菜花卉研究所 成都 论坛 信息 生物技术 研究室 编辑部 |
Effects of gastric electrical stimulation on the activity of gastric distension sensitive neuron in VMH and the expression of oxytocin in rat brain |
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| SUN Xiang-rong,XU Luo,ZHONG Feng.Effects of gastric electrical stimulation on the activity of gastric distension sensitive neuron in VMH and the expression of oxytocin in rat brain[J].Acta Horticulturae Sinica,2007,34(3):574-578. |
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| Authors: | SUN Xiang-rong XU Luo ZHONG Feng |
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| Institution: | Department of Pathophysiology, Qingdao University Medical College, Qingdao 266021, China. E-mail: luoxukai@yahoo.com |
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| Abstract: | AIM:To study the central mechanism of gastric electrical stimulation (GES) in treating obesity in rats by observing the effects of GES on gastric distension (GD) sensitive neurons in ventromedia hypothalamus (VMH) and the expression of oxytocin (OT) in brain. METHODS:The effects of GES on GD sensitive neurons in VMH were observed by recording extracellular potentials of single neurons. GD sensitive neurons were classified as GD-E neurons and GD-I neurons according to the response to GD. GES with two sets (GES1 and GES2) of parameters was applied for one minute. On the other hand, the expression of oxytocin in PVN and SON was observed by fluo-immunohistochemistry staining using GES1. RESULTS:(1) 60.4% and 75.0% GD sensitive neurons were excited by GES1 and GES2， respectively (P>0.05). The firing varied rate of GD-E neurons to GES2 was significantly greater than that to GES1 (343.59%±89.19% vs 97.44%±33.67%, P<0.05), the same results in GD-I neurons (366.30%±87.20% vs 112.00%±14.67%, P<0.05) was also observed. (2) The expressions of OT immunoreactive (OT-IR) positive neurons were significantly increased in PVN (P<0.01) and SON (P<0.05) using GES1 for 2 h. CONCLUSION:These results indicate that GES may inhibit feeding by exciting the activity of GD sensitive neurons in VMH and increase the expression of OT in brain. The excitatory effect of GES is related to the strength of stimulation. |
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| Keywords: | Gastric electrical stimulation Ventromedial hypothalamic nucleus Oxytocin Rats |
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