Bioavailability of ketoprofen in horses after rectal administration |
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| Authors: | S CORVELEYN P DEPREZ† G VAN DER WEKEN‡ W BAEYENS‡ J P REMON |
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| Institution: | Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences;Department of Internal Diseases of Large Animals, Faculty of Veterinary Medicine;Laboratory of Drug Quality analysis, Faculty of Pharmaceutical Sciences, Universiteit Gent, 9000 Gent, Belgium |
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| Abstract: | Six healthy mares ranging in age from 6 to 12 years and weighing from 415 to 540 kg were used to determine the rectal bioavailability of ketoprofen. For the rectal administration, three different formulations, each containing 1 g of ketoprofen, were administered in a fatty and a hydrophilic suppository base and as a liquid suspension. An average elimination half-life of 1.3 h (±1.2) was found. The average value for the total plasma clearance ( Cl T) was 131.9 mL/min.kg (range 95-183.5). The volume of distribution V d(area) was 255 mL/kg and the mean residence time (MRT)P = 0.05; Friedman test). Despite the low rectal bioavailability obtained in this study, there was some evidence for the clinical effectiveness of the rectal formulations. |
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