| 仔猪感染猪等孢球虫后T细胞亚群的动态变化 |
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| 引用本文： | 王芳,宁长申,张龙现,菅复春,朱静静,姚雷,张敏.仔猪感染猪等孢球虫后T细胞亚群的动态变化[J].中国农学通报,2007,23(9):24-27. |
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| 作者姓名： | 王芳 宁长申 张龙现 菅复春 朱静静 姚雷 张敏 |
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| 作者单位： | 河南农业大学牧医工程学院 郑州450002 |
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| 基金项目： | 河南省自然科学基金重点项目“猪球虫病流行病学调查及致病种生物学特性研究”(0311032400) |
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| 摘 要： | 为了研究仔猪感染猪等孢球虫后T细胞亚群的变化规律,应用纯种猪等孢球虫孢子化卵囊人工感染9头6日龄仔猪,分别检测了感染前1d和感染后1、3、6、9、11d(DPI)外周血中CD3 、CD4 、CD8 T细胞。结果显示,DPI3,CD3 、CD4 T细胞增加,之后下降,但差异均不显著(p>0.05);CD8 T细胞在DPI6增加,DPI 9达峰值(P<0.05)。CD4 /CD8 值在DPI 6下降,DPI 11达到最低点。表明DPI 3感染仔猪的免疫功能有所增强,而DPI 8后仔猪免疫功能受到抑制。
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| 关 键 词： | 仔猪 猪等孢球虫 CD3~ T细胞 CD4~ T细胞 CD8~ T细胞 |
| 修稿时间： | 2007-05-14 |
Dynamic Observation on the T Lymphocyte Subgroups of Piglets Infected with Isospora suis |
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| Wang Fang, Ning Changshen, Zhang Longxian, Jian Fuchun, Zhu Jingjing,Yao Lei, Zhang Min.Dynamic Observation on the T Lymphocyte Subgroups of Piglets Infected with Isospora suis[J].Chinese Agricultural Science Bulletin,2007,23(9):24-27. |
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| Authors: | Wang Fang Ning Changshen Zhang Longxian Jian Fuchun Zhu Jingjing Yao Lei Zhang Min |
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| Institution: | The College of A nimal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002 |
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| Abstract: | In order to reveal the dynamic changes of the T lymphocyte subgroups in piglets,nine six-day-old piglets were inoculated with Isospora suis sporulated occysts. CD3 , CD4 , CD8 T cells were checked on before and post the day inoculation 1, 3, 6, 9, 11 (DPI), respectively. Results showed that the amounts of CD3 , CD4 T cells increased on DPI 3 and then decreased, but the diversity was not significant (p>0.05); however, CD8 T cell raised on DPI 6 and reached peak value on DPI 9 (P<0.05). The ratio of CD4 /CD8 began to descend on DPI 6, and came to the lowest point on DPI 11. Those indicated that the immunological functions of the piglets infected with I. suis were reinforced on DPI 3, however, which were suppressed after DPI 8 . |
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| Keywords: | Piglets Isospora suis CD3~ T cell CD4~ T cell CD8~ T cell |
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