| 产蛋鸡卵母细胞卵黄生成受体(OVR)的研究进展 |
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| 引用本文： | 崔学平,陈代文,张克英.产蛋鸡卵母细胞卵黄生成受体(OVR)的研究进展[J].饲料工业,2007,28(9):17-20. |
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| 作者姓名： | 崔学平 陈代文 张克英 |
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| 作者单位： | 四川农业大学动物营养研究所,625014,四川雅安 |
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| 摘 要： | OVR介导大量的血浆蛋白被产蛋鸡吸收到生长的卵母细胞中,是卵黄前体进入卵母细胞的瓶颈。到目前为止发现它不仅与最丰富、最重要的卵黄前体极低密度脂蛋白(VLDL)、卵黄蛋白原(VTG)结合,还结合丛生蛋白、α2-巨球蛋白(α2-M)、受体相关蛋白(RAP)、乳铁蛋白、核黄素结合蛋白(ribBP)等,这些成分占蛋黄干物质的绝大部分。OVR发生突变的蛋鸡,不能繁殖,并且具有严重的高脂血症。它所内吞的VLDL的数量是蛋黄胆固醇含量的决定因素,因此期望通过调控OVR来控制蛋黄胆固醇的含量。
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| 关 键 词： | 产蛋鸡 卵母细胞卵黄生成受体(OVR) 胆固醇 脂蛋白 |
| 修稿时间： | 2007-01-23 |
Advance in oocyte vitellogenesis receptor of the laying hen |
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| Cui Xueping,Chen Daiwen,Zhang Keying.Advance in oocyte vitellogenesis receptor of the laying hen[J].Feed Industry,2007,28(9):17-20. |
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| Authors: | Cui Xueping Chen Daiwen Zhang Keying |
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| Abstract: | Oocyte vitellogenesis receptors(OVR) mediates the uptake of plasma proteins into growing oocytes of laying hen, a choke point of yolk precursors into oocytes. Quantitatively important yolk precursors are very low density lipoproteins and vitellogenin. Up to now, OVR is not only the receptor for both of these ligands ,but also for clusterin,α2-Macrogl'obulin, Receptor-associated Protein(RAP), lactoferrin, Riboflavin binding protein (ribBP) and so on. They are major constituents of yolk solids form. Mutant strain hens lacking functional OVR are sterile and display severe hyperlipidemia. The content of egg yolk cholesterol depends on the amount of VLDL transported into oocyte.It is hopeful to control the content of egg cholesterol by modifying OVR. |
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| Keywords: | laying hen oocyte vitellogenesis receptor cholesterol lipoprotein |
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