Efficacy and toxicity of paclitaxel (Taxol) for the treatment of canine malignant tumors |
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| Authors: | Poirier V J Hershey A E Burgess K E Phillips B Turek M M Forrest L J Beaver L Vail D M |
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| Institution: | Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA. |
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| Abstract: | Paclitaxel (Taxol) was administered to 25 dogs with histologically confirmed malignant tumors at a dosage of 165 mg/m2 i.v. over 3-6 hours every 3 weeks. Dogs received premedication with antihistimines and corticosteroids to reduce hypersensitivity reactions. However, 64% of the dogs still experienced allergic reactions. Six dogs (24%) had grade 3 or 4 neutropenia, 6 dogs (24%) required hospitalization and 3 dogs (12%) died of sepsis. Five dogs (20%) had a partial response (osteosarcoma 2 dogs] mammary carcinoma 2 dogs] and malignant histiocytosis 1 dog]) for a median duration of 53 days. The overall toxicity was unacceptable at the 165 mg/m2 dose. Therefore, subsequent evaluations of paclitaxel in tumor-bearing dogs should a starting dose of 132 mg/m2 i.v. every 3 weeks. |
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| Keywords: | Dog Malignant histiocytosis Mammary carcinoma Osteosarcoma |
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