The apparent in vivo neuromuscular effects of the δ-endotoxin of Bacillus thuringiensis var. israelensis in mice and insects of four orders |
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| Authors: | Peter YK Cheung Richard M Roe Bruce D Hammock Charles L Judson Mary Ann Montague |
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| Institution: | 1. Department of Entomology, University of California, Davis, California 95616 USA;2. Department of Environmental Toxicology, University of California, Davis, California 95616 USA |
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| Abstract: | Alkaline-dissolved crystal δ-endotoxin from Bacillus thuringiensis var. israelensis (serovar H 14) was injected into mice and seven species of insects representing the orders Lepidoptera, Orthoptera, Coleoptera, Hemiptera, and Diptera. High in vivo toxicity, at 1 to 5 ppm (μg toxin/g body wet wt), was observed with mice and some insects, including some that are not sensitive to the toxin when administered orally. Neuromuscular effects were observed when the toxin was injected directly into the body cavity of the test animals. Biochemical studies suggested that different protein fragments within the crystal δ-endotoxin may be responsible for the majority of the mosquito larvacidal activity and the neurotoxic symptoms observed in larvae of Trichoplusia ni. |
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| Keywords: | To whom inquiries should be addressed |
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