Structure of a 16-nm cage designed by using protein oligomers |
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| Authors: | Lai Yen-Ting Cascio Duilio Yeates Todd O |
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| Institution: | University of California Los Angeles Biomedical Engineering Interdepartmental Program, Los Angeles, CA 90095, USA. |
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| Abstract: | Designing protein molecules that will assemble into various kinds of ordered materials represents an important challenge in nanotechnology. We report the crystal structure of a 12-subunit protein cage that self-assembles by design to form a tetrahedral structure roughly 16 nanometers in diameter. The strategy of fusing together oligomeric protein domains can be generalized to produce other kinds of cages or extended materials. |
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