|
|||||
|
|
Nucleotide sequence homology to bovine viral diarrhea virus 2 (BVDV 2) in the 5′ untranslated region of BVDVs from cattle with mucosal disease or persistent infection in Japan |
|
| Authors: | M Nagai M Sato H Nagano H Pang X Kong T Murakami T Ozawa and H Akashi |
| Institution: | a Nanbu Livestock Hygiene Service Center, Ishikawa Prefecture, Saida, Kanazawa, Ishikawa 920-3101, Japan b Utsunomiya Livestock Hygiene Service Center, Tochigi Prefecture, Wakakusa, Utsunomiya, Tochigi 320-0072, Japan c Gifu Livestock Hygiene Service Center, Gifu Prefecture, Imamine, Gifu, Gifu 500-8388, Japan d National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki 305-0856, Japan |
| Abstract: | Cytopathogenic and non-cytopathogenic bovine viral diarrhea viruses (BVDVs) were isolated from cattle with mucosal disease or persistent infection in Japan. These isolates were compared for antigenic properties by cross-neutralization tests with Japanese reference strains of BVDV belonging to classical type 1. Significantly low cross-reactivity to reference strains was noted, indicating the viruses to possibly represent a new serotype in Japan. Thus, to determine the genotype of the isolates, nucleotide sequences of the 5′ untranslated region were determined and compared with those of previously reported BVDV 1 and 2. The isolates were clearly shown to belong to BVDV 2, not to BVDV 1. |
| Keywords: | BVDV 2 Mucosal disease New Japanese serotype Persistent infection 5′ UTR |
| 本文献已被 ScienceDirect 等数据库收录！ | |