| 5—氨基—4—咪唑—N—琥珀酸羧基酰胺核糖核苷酸的合成 |
| |
| 引用本文： | 周跃钢 Atki.,CA.5—氨基—4—咪唑—N—琥珀酸羧基酰胺核糖核苷酸的合成[J].西南农业大学学报,1992,14(2):172-176. |
| |
| 作者姓名： | 周跃钢 Atki. CA |
| |
| 作者单位： | 西南农业大学生物学部
(周跃钢)，西澳大利亚大学(Atkins C.A.) |
| |
| 摘 要： | 5-氯基-4-咪唑-N-琥珀酸羧基酰胺核糖核苷酸(SAICAR)是从头嘌呤合成中的双功能酶腺苷酸琥珀酸裂解酶(EC 4、3、2、2)的底物之一,被成功地用腺苷酸琥珀酸裂解酶合成.从72.00×10~(-?)mmol的5-氨基-4-咪唑羧基酰胺核糖核苷酸(AICAR)得到43.78×10~(-3)mmol的SAICAR,产率约为AICAR的60.8%.
|
| 关 键 词： | SAICAR 合成 |
SYNTHESIS OF 5-AMINO-4-IMIDAZOLE-N-SUCCINOCARBOXAMIDE RIBONUCLEOTIDE (SAICAR) |
| |
| Zhou Yuegang.SYNTHESIS OF 5-AMINO-4-IMIDAZOLE-N-SUCCINOCARBOXAMIDE RIBONUCLEOTIDE (SAICAR)[J].Journal of Southwest Agricultural University,1992,14(2):172-176. |
| |
| Authors: | Zhou Yuegang |
| |
| Abstract: | SAICAR,a substrate of adenylosuccinate lyase,which is a bifunctional enzyme in denovo purine synthesis pathway,was successfully synthesized with adenylosuccinate lyasefrom yeast.The synthetic SAICAR was purified on an ionexchange chromatographic col-umn before undergoing a further purification treatment.The processes of systhesis and iso-lation were monitored by HPLC sampling.Its yield was approximately 43.78 micromoles,representing a yield of 60.8% based on SAICAR. |
| |
| Keywords: | SAICAR synthesis |
| 本文献已被 CNKI 维普 等数据库收录！ |
