Carcinoma of the mammary gland in a mare |
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| Authors: | L Bussche C Harms E L Buckles D Whelchel M Brosnahan G R Van de Walle |
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| Institution: | 1. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA;2. Southern Equine Service, Aiken, South Carolina, USA;3. Rood and Riddle Equine Hospital in Saratoga, New York, USA;4. Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA;5. Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, USA |
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| Abstract: | A 20‐year‐old Quarter Horse mare was presented with a firm, nonpainful swelling near the axial margin of the left mammary gland. Ultrasound examination of the mass revealed a 35 mm poorly encapsulated, homogeneous mass within the parenchyma of the left mammary gland. Using histopathology and immunohistochemistry, the mass was diagnosed as a mammary carcinoma and showed positivity for cytokeratin 18 (CK18), vimentin and α‐smooth muscle actin. Additionally, the mRNA expression level of the oncogene cMyc did not show a significant upregulation, whereas p53, a well‐known tumour suppressor gene in breast cancer, was significantly reduced in comparison with healthy equine mammary gland tissue. To the authors' knowledge, this is the first report of a significant downregulation of p53 expression in a mammary carcinoma of a mare. |
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| Keywords: | horse carcinoma mammary gland
p53
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