| 负载戊唑醇的聚乙二醇-聚己内酯胶束的制备与性能研究 |
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| 引用本文： | 张旭,周月英,陈安良,张绍勇,何伟娜,徐君庭,孙芳利.负载戊唑醇的聚乙二醇-聚己内酯胶束的制备与性能研究[J].农药学学报,2012,14(3):327-333. |
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| 作者姓名： | 张旭 周月英 陈安良 张绍勇 何伟娜 徐君庭 孙芳利 |
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| 作者单位： | 1.浙江农林大学 森林保护研究所, 浙江 临安 311300 |
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| 基金项目： | 国家自然科学基金面上项目2010-2012(30972304). |
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| 摘 要： | 通过开环聚合法合成了聚乙二醇-聚己内酯嵌段共聚物(PEG-b-PCL),以PEG-b-PCL为囊壁、以戊唑醇为囊芯,采用自组装的方法制备了载药胶束。分别利用动态光散射仪(DLS)和透射电镜(TEM) 对其粒径进行了表征,通过紫外分光光度计和高效液相色谱仪测定了其载药量、包覆率和体外释药性能,用滤纸片法测试了载药胶束对木霉 Trichoderma viride 的抑菌性能。结果表明:PEG-b-PCL载戊唑醇胶束平均粒径为 250 nm,均匀度良好,载药量为 26.4%,包覆率为18.0%,体外释放192 h的释药率为83.35%,其对木霉的抑菌效果明显高于同浓度下的戊唑醇乙酸乙酯溶液。
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| 关 键 词： | 聚乙二醇-聚己内酯嵌段共聚物 戊唑醇 载药胶束 抑菌作用 |
| 收稿时间： | 2012/1/19 0:00:00 |
| 修稿时间： | 2012/2/16 0:00:00 |
Preparation and performances of poly(ethyleneglycol)- polycaprolactone micelles loaded with tebuconazole |
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| ZHANG Xu,ZHOU Yueying,CHEN Anliang,ZHANG Shaoyong,HE Wein,XU Junting and SUN Fangli.Preparation and performances of poly(ethyleneglycol)- polycaprolactone micelles loaded with tebuconazole[J].Chinese Journal of Pesticide Science,2012,14(3):327-333. |
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| Authors: | ZHANG Xu ZHOU Yueying CHEN Anliang ZHANG Shaoyong HE Wein XU Junting and SUN Fangli |
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| Institution: | 1.School of Forestry and Biotechnology, Zhejiang A & F University, Lin’an 311300, Zhejiang Province, China2.Provincial Engineering Laboratory of Biopesticide Preparation, Zhejiang Province Lin’An 311300, China3.School of Engineering, Zhejiang A & F University, Lin’an 311300, Zhejiang Province, China4.Institute of Polymer Science, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | The poly(ethylene glycol)-polycaprolactone(PEG- b -PCL) block copolymer was synthesized by ring-opening polymerization method,and the self-assembled PEG- b -PCL micelles was applied as carrier to load tebuconazole by self-assembly method.The diameter of the tebuconazole loaded micelles was characterised by dynamic light scattering(DLS) and transmission electron microscope(TEM).The drug loading efficiency,encapsulation rate and release characteristics in vitro were measured by ultraviolet specrophotometer and high performance liquid chromatography(HPLC).The mould inhibition properties of tebuconazole-loaded micelles to Trichoderma viride was evaluated by filter paper method.Results showed that tebuconazole loaded PEG-b-PCL micelles were spherical and uniform,with a mean particle diameter of 250 nm.The drug loading efficiency and encapsulation rate were 26.4% and 18% respectively.Tebuconazole-loaded PEG-b-PCL micelles showed good slow-release characteristics.After 192 h,the drug release percentage of tebuconazole-loaded PEG-b-PCL micelles was 83.35%.Tebuconazole-loaded PEG-b-PCL micelles also exhibited more efficient mould inhibitions to T. viride than that of tebuconazole-ethyl acetate solution. |
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| Keywords: | PEG-b-PCL block copolymer tebuconazole drug loaded micelles inhibition zone |
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