| 二氟甲基取代吡唑甲酰胺类化合物的合成及杀菌活性 |
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| 引用本文： | 张秋颖,彭伟立,孔小林,曹敏,姚巍,胡伟群,谭成侠.二氟甲基取代吡唑甲酰胺类化合物的合成及杀菌活性[J].农药学学报,2012,14(3):345-348. |
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| 作者姓名： | 张秋颖 彭伟立 孔小林 曹敏 姚巍 胡伟群 谭成侠 |
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| 作者单位： | 1.浙江工业大学 化学工程与材料学院, 杭州 310014 |
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| 基金项目： | 浙江工业大学化学工程与新材料研究生教育创新示范基地资助课题(2013);"十二五"国家科技支撑计划项目(2011BAE06B02-04)子课题资助. |
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| 摘 要： | 以二氟乙酰乙酸乙酯和原甲酸三乙酯为起始原料,经亲核取代、环化、水解、氯代和酰化反应得到N-(1-甲基-2-羟乙基)-3-二氟甲基-1-甲基-1 H -吡唑-4-酰胺(4),4与取代异氰酸酯作用,合成了10个未见文献报道的二氟甲基取代吡唑甲酰胺类衍生物,其结构均经过1H NMR和MS分析确证。初步生物活性测试结果表明,在50 mg/L下,目标化合物 ZJ-3、ZJ-5、ZJ-7、ZJ-8 对瓜类炭疽病菌、瓜类灰霉病菌和水稻纹枯病菌具有一定的杀菌活性。
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| 关 键 词： | 吡唑甲酰胺 合成 杀菌活性 |
| 收稿时间： | 2012/2/10 0:00:00 |
| 修稿时间： | 2012/3/10 0:00:00 |
Synthesis and fungicidal activity of difloromethyl-1H- pyrazole-4-carboxamides |
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| ZHANG Qiuying,PENG Weili,KONG Xiaolin,CAO Min,YAO Wei,HU Weiqun and TAN Chengxia.Synthesis and fungicidal activity of difloromethyl-1H- pyrazole-4-carboxamides[J].Chinese Journal of Pesticide Science,2012,14(3):345-348. |
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| Authors: | ZHANG Qiuying PENG Weili KONG Xiaolin CAO Min YAO Wei HU Weiqun and TAN Chengxia |
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| Institution: | 1.College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China2.Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China |
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| Abstract: | Ten novel difluoromethyl substituted pyrazolecarboxamide derivatives were synthesized with nucleophilic substitution,cyclization,hydrolysis,esterification and addition reaction using ethyl 4,4-difluoro-3-oxobutanoate and triethoxymethane as raw materials.Their structures were confirmed by 1H NMR and MS.The preliminary bioassay showed that target compounds ZJ-3,ZJ-5,ZJ-7 and ZJ-8 exhibit some inhibiting effects against Gibberella zeae,Botrytis cinerea and Rhizoctonia solani at the concentration of 50 mg/L. |
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| Keywords: | pyrazolecarboxamide compounds synthesis fungicidal activity |
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