| 正交试验法优化速派颗粒中牡丹皮活性成分提取工艺 |
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| 引用本文： | 徐登基,兰新财,缪雪荣,肖琛闻,何绣锦,施佩.正交试验法优化速派颗粒中牡丹皮活性成分提取工艺[J].中兽医医药杂志,2012,31(2):8-12. |
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| 作者姓名： | 徐登基 兰新财 缪雪荣 肖琛闻 何绣锦 施佩 |
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| 作者单位： | 1. 浙江金大康动物保健品有限公司,浙江金华,321016
2. 浙江省农业科学院畜牧兽医研究所 |
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| 基金项目： | 金华市科技局重点科研项目“中药制剂防治猪高热综合征的研发”(项目编号:2008-2-005) |
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| 摘 要： | 目的:优化速派颗粒中牡丹皮活性成分的提取工艺。方法:以芍药苷和丹皮酚为指标,通过正交试验考察不同因素和水平对提取工艺的影响。结果:芍药苷的最佳提取工艺是70%乙醇、提取温度80℃、乙醇用量12倍、提取时间0.5 h;丹皮酚的最佳提取工艺是蒸馏时间为4 h、收集8倍液量、0℃冷藏36 h。结论:该提取工艺合理、可行,可为大生产提供实验依据。
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| 关 键 词： | 速派 芍药苷 丹皮酚 高效液相色谱法 正交试验 |
Optimization on the extracting process of tree peony bark from Super granules with orthogonal design |
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| XU Deng-ji,LAN Xin-cai,MIAO Xue-rong,HE Xiu-jin,SHI Pei.Optimization on the extracting process of tree peony bark from Super granules with orthogonal design[J].Journal of Traditional Chinese Veterinary Medicine,2012,31(2):8-12. |
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| Authors: | XU Deng-ji LAN Xin-cai MIAO Xue-rong HE Xiu-jin SHI Pei |
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| Institution: | (Zhejiang Jindkcom Animal Health Business Co.,Ltd,Jinhua Zhejiang 321016,China) |
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| Abstract: | Objective: To optimize the extracting process of tree peony bark from Super granules.Methods: Orthogonal experiment was carried out with paeoniflorin and paeonol as the detective marker.Results: The optimum extracting condition for paeoniflorin was that adding twelve fold volume of 70% ethanol at 80 ℃ for 0.5 hour;while optimum extracting condition for paeonol was that four hours of distillation,eight fold volume of collection liquid and 36 hours of refrigeration at 0 ℃.Conclusion: The suitable and practicable extracting process could provide experiment data for factory production. |
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| Keywords: | Super granules paeoniflorin paeonol HPLC orthogonal design |
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