| L-苯丙氨酸对小鼠妊娠早期胚胎发育及子宫局部肥大细胞的影响 |
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| 引用本文： | 董玉兰,白永平,王子旭,陈耀星,李素琪,韩亚楠,刘冠慧.L-苯丙氨酸对小鼠妊娠早期胚胎发育及子宫局部肥大细胞的影响[J].中国兽医杂志,2012,48(5):6-9,97. |
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| 作者姓名： | 董玉兰 白永平 王子旭 陈耀星 李素琪 韩亚楠 刘冠慧 |
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| 作者单位： | 1. 中国农业大学动物医学院,北京海淀,100193
2. 中国农业大学动物医学院,北京海淀100193;中国农业科学院北京畜牧兽医研究所,北京海淀100193 |
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| 基金项目： | 教育部博士点新教师基金(200800191004);国家大学生创新训练计划(101001919);国家自然科学基金(30700575) |
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| 摘 要： | 为了研究交感神经对小鼠胚胎着床和发育的作用机制,本文筛选出合适的L-苯丙氨酸浓度(320 mg/kg体重),处理孕鼠,观察胚胎着床和发育,通过甲苯胺蓝染色检测子宫局部肥大细胞的变化.研究结果显示,320 mg/kg体重L-苯丙氨酸能显著降低胚胎着床数目,分别下降了45％ (E7)和58％(E9),并且显著延缓胚胎的发育；与对照组相比,着床后子宫局部肥大细胞数目显著降低,分别在E5～E9降低了36.62％、64.59％和23.30％,差异显著.由本研究结果可以推断一定浓度的L-苯丙氨酸可以激活交感神经,影响妊娠早期子宫局部肥大细胞数量,从而改变子宫局部微环境,影响胚胎着床和发育.
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| 关 键 词： | L-苯丙氨酸 胚胎着床 肥大细胞 |
The influence of L-phenylalanine on the embryo development and uterus mast cells in early pregnant mice |
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| DONG Yu-lan
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BAI Yong-ping
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WANG Zi-xu
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CHEN Yao-xing
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LI Su-qi
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HAN Ya-nan
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LIU Guan-hui.The influence of L-phenylalanine on the embryo development and uterus mast cells in early pregnant mice[J].Chinese Journal of Veterinary Medicine,2012,48(5):6-9,97. |
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| Authors: | DONG Yu-lan BAI Yong-ping WANG Zi-xu CHEN Yao-xing LI Su-qi HAN Ya-nan LIU Guan-hui |
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| Institution: | 1(1.College of Animal Medicine,China Agricultural University,Beijing 100193,China; 2.Institute of Animal Science,Chinses Academy of Agricultural Sciences,Beijing 100193,China) |
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| Abstract: | The purpose of this study is to investigate the role sympathetic nerve on the embryo implantation.The pregnant mice were treated by a suitable concentration of L-phenylalanine(320 mg/kg) and tested the number of mast cells by toluidine blue staining.The results showed that the number of embryo implantation decreased significantly by 45%(E7) and 58%(E9),and delayed the development of embryos in the treated mice;The number of mast cells decreased by 36.62%、64.59% and 23.30% at E5, E7 and E9.The results suggest that L-phenylalanine with suitable concentration might activate the sympathetic nerve,and change the number of mast cells,which induces abnormal the uterus local microenviroment and play a harmful role in the implantation and development of embryo. |
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| Keywords: | L-phenylalanine embryo implantation mast cells |
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