Effects of Triiodothyronine-induced Hyperthyroidism on Lipid Peroxidation,Erythrocyte Resistance and Iron-binding and Iron-oxidizing Antioxidant Properties of Plasma in the Rabbit |
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| Authors: | Email author" target="_blank">E?Brzezińska-?lebodzińskaEmail author |
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| Institution: | (1) Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences in Olsztyn, Department of Hormonal Action Mechanisms, ul. Grunwaldzka 250, 60-166, Poznań, Poland |
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| Abstract: | The effect of hyperthyroidism on some oxidative stress parameters is reported. The hyperthyroid state was induced by intraperitoneal
injection of triiodothyronine (T3)(10 μg/kg body weight) for 14 days in two groups of female rabbits (3 and 12 months old). The T3 injection caused increase by 1.5-fold to 1.7-fold in T3 serum level, and 2-fold to 3-fold decrease (age-dependent) in body weight gain at the end of experimental period. The induced
hyperthyroidism caused a significant increase in the serum concentration of the lipid peroxidation end-product malondialdehyde
and lowered erythrocyte resistance to oxidative stress when subjected to the free radical generator 2,2'-azobis(2-amidinopropane)
hydrochloride in vitro. The half maximum haemolysis time (HT50) decreased in the both experimental groups of rabbits, by about 12 min in the 3-month-old animals and 27 min in the 12-month-old
animals. The study showed for the first time that hyperthyroidism enhances the ability of plasma to protect against iron-binding
and iron oxidizing organic radicals. The scavenging property and antioxidant capacity of plasma against iron-binding inorganic
radicals also increased. Measurement of erythrocyte resistance to oxidative stress and the protective ability of plasma against
oxygen radicals discriminates the thyroid hormone modulatory effects in defence mechanisms against lipid peroxidation. |
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| Keywords: | free radicals hyperthyroidism lipid peroxidation oxidative stress red cells |
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