Cytotoxic pentacyclic triterpenes from Combretum nigricans |
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| Authors: | Simon G Dewelle J Nacoulma O Guissou P Kiss R Daloze D Braekman J C |
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| Institution: | Unibioscreen SA, EEBIC, 40 Av. J. Wybran, Brussels 1070, Belgium. |
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| Abstract: | A new pentacyclic triterpene, 11alpha-acetoxy-20,24-epoxy-25-hydroxy-dammar-3-one (1), has been isolated from the African tree Combretum nigricans, together with the known corresponding diol, 20,24-epoxy-11alpha, 25-dihydroxy-dammar-3-one (2). They are responsible, at least in part, for the cytotoxic activity of the methanolic extract of the plant. |
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