| 鹿、牛基因组不同区域的微小变异研究 |
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| 引用本文： | 巴恒星,杨福合,李春.鹿、牛基因组不同区域的微小变异研究[J].特产研究,2012(2):1-4,8. |
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| 作者姓名： | 巴恒星 杨福合 李春 |
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| 作者单位： | 中国农业科学院特产研究所吉林省特种经济动物分子生物学省部共建实验室,吉林吉林132109 |
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| 摘 要： | 本研究借助鹿和牛基因组序列,通过同源序列比较的方法研究远缘物种基因组不同区域的微小变异,包括单碱基突变、小片段插入和删除.研究结果验证了基因组功能区的点突变和删除变异相对非功能区是保守的普遍性结论.点突变变异与删除变异在鹿、牛基因组不同区域上表现强的正相关性.比较近缘物种人、黑猩猩基因组点突变变异数据,表明牛、鹿基因组的功能区和非功能区突变速率各自保持大致恒定,符合分子钟理论
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| 关 键 词： | 远源物种 基因组 单碱基突变 插入和删除 |
Micro- Variation in Different Regions between Deer and Cattle Genome Sequences |
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| BA Heng-xing,YANG Fu-he,LI Chun-yi.Micro- Variation in Different Regions between Deer and Cattle Genome Sequences[J].Special Wild Economic Animal and Plant Research,2012(2):1-4,8. |
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| Authors: | BA Heng-xing YANG Fu-he LI Chun-yi |
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| Institution: | (State Key Laboratory of Special Economic Animal Molecular Bioloy Institute of Special Wild Economic Animals and Plants,Chinese Academy of Agricultural Sciences,Jilin,132109,China) |
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| Abstract: | In this study,sika deer genome sequence was used to compare with the cattle reference genome using the methods of homology comparison,which was used to identify the Micro-Variation in different regions between distant species genomes in the past.These Micro-Variations consisted of point mutation variations(SNP) and small nucleotide insertion and deletion variations(Indel).The results verified the general conclusion that the variations of SNP and Indel in the functional regions are more conservative than in the non-functional regions.Also,the results showed a strong positive correlation between the SNP variations and Indel variations among different regions.The variation data between human and chimpanzee are compared with those of this study.The results verified that the mutation rate has kept in consistent in the genome functional regions and non-functional regions respectively.The results validated once again the theory of molecular clock. |
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| Keywords: | Distant species Genomes SNP Indel |
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