| 盐酸赛拉嗪对家兔麻醉效果的研究 |
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| 引用本文： | 盐酸赛拉嗪对家兔麻醉效果的研究.盐酸赛拉嗪对家兔麻醉效果的研究[J].畜牧与饲料科学,2022,43(6):114-118. |
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| 作者姓名： | 盐酸赛拉嗪对家兔麻醉效果的研究 |
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| 作者单位： | 新疆农业大学动物医学学院，新疆 乌鲁木齐 830052 |
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| 基金项目： | 新疆维吾尔自治区天山雪松计划(2020XS06);新疆农业大学大学生创新项目(dxscx2020167) |
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| 摘 要： | 目的]探究盐酸赛拉嗪对家兔的麻醉效果。方法]选取新西兰兔12只，随机分为耳缘静脉注射（IV）保定组、臀部肌肉注射（IM）保定组、IV未保定组、IM未保定组，每组3只；按照不同给药途径给予家兔3 mg/（kg·BW）盐酸赛拉嗪，给药后保定处理方式为仰卧保定四肢及头部，未保定的家兔自然俯卧；第1次给药后30 min，再以相同给药途径给予家兔2 mg/（kg·BW）盐酸赛拉嗪；于给药前10 min以及第2次给药后5、30、60 min监测家兔基本生命体征及麻醉反应指标。结果]给予盐酸赛拉嗪后不同时间，4组家兔呼吸频率和脉搏次数与给药前相比均显著（P<0.05）或极显著（P<0.01）降低；给药后60 min IM保定组脉搏次数最低，显著（P<0.05）低于IV未保定组。4组家兔给药后30 min直肠温度与给药前相比均显著（P<0.05）降低；除IV未保定组外，给药后60 min各组家兔直肠温度与给药前相比极显著（P<0.01）降低；给药后60 min IM保定组的直肠温度最低，极显著（P<0.01）低于IV未保定组。IM保定组家兔给药后不同时间均未出现翻正反射、睫毛反射和疼痛反射；IV未保定组在给药后60 min，3只家兔均出现翻正反射、睫毛反射和疼痛反射。IM保定组家兔的麻醉期最长，显著（P<0.05）长于IV保定组，极显著（P<0.01）长于IV未保定组和IM未保定组。结论]用盐酸赛拉嗪麻醉家兔时应使用IM给药途径，推荐首次给药剂量为3 mg/（kg·BW），之后30 min再补充2 mg/（kg·BW），给药后应即刻保定确实。
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| 关 键 词： | 盐酸赛拉嗪 家兔 保定 麻醉期 |
| 收稿时间： | 2022-04-28 |
Anesthetic Effect of Xylazine Hydrochloride in Rabbits |
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| Wei-fang GU,Hui-min WU,Fei-fan ZHANG,Guli·Tursun Reyihan,Guo-qing LI,Hong-qiong ZHAO.Anesthetic Effect of Xylazine Hydrochloride in Rabbits[J].Animal Husbandry and Feed Science,2022,43(6):114-118. |
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| Authors: | Wei-fang GU Hui-min WU Fei-fan ZHANG Guli·Tursun Reyihan Guo-qing LI Hong-qiong ZHAO |
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| Institution: | College of Veterinary Medicine，Xinjiang Agricultural University，Urumqi 830052，China |
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| Abstract: | Objective] The present study aimed to assess the anesthetic effect of xylazine hydrochloride in rabbits. Method] Twelve New Zealand rabbits were assigned into the following four groups at random with 3 rabbits in each group: an ear intravenous injection （IV） with fixation group, a buttocks intramuscular injection （IM） with fixation group, an ear IV without fixation group, and a buttocks IM without fixation group. The rabbits in different groups were given xylazine hydrochloride at a dosage of 3 mg/（kg·BW） by corresponding administration approaches. After administration, the rabbits in the fixation groups were in supine position with head and limbs fixed, and those in the non-fixation groups were in natural prone position. Thirty min post the first administration, the rabbits were given xylazine hydrochloride again at a dosage of 2 mg/（kg·BW） by the same approach as the first administration. Basic vital signs and anesthetic reaction indexes of the rabbits were monitored 10 min prior to administration as well as 5, 30 and 60 min post the second administration. Result] The respiratory and pulse frequencies of the four groups after administration of xylazine hydrochloride decreased significantly or extremely significantly （P<0.05 or P<0.01） compared with those before administration. At 60 min after administration, the pulse frequency of IM fixation group was the lowest, which was significantly （P<0.05） lower than that of IV non-fixation group. The rectal temperature of the four groups at 30 min after administration was significantly （P<0.05） lower than that before administration. Except for the IV non-fixation group, the rectal temperature of each group at 60 min after administration was extremely significantly （P<0.01） lower than that before administration. At 60 min after administration, the rectal temperature of IM fixation group was the lowest, which was extremely significantly （P<0.01） lower than that of IV non-fixation group. In IM fixation group, no righting reflex, eyelash reflex and pain reflex were observed at different time points after administration. In IV non-fixation group, the righting reflex, eyelash reflex and pain reflex were observed in all 3 rabbits at 60 min after administration.The anesthetic period of IM fixation group was the longest, which was significantly （P<0.05）longer than that of IV fixation group and was extremely significantly （P<0.01） longer than that of IV non-fixation group and IM non-fixation group. Conclusion] Xylazine hydrochloride should be administered by the route of IM in anesthesia of rabbits. A first administration at the dosage of 3 mg/（kg·BW） is recommended, and a subsequent administration at the dosage of 2 mg/（kg·BW） should be given 30 min later. The rabbits should be fixed immediately after administration. |
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| Keywords: | xylazine hydrochloride rabbit fixation anesthetic period |
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