| 基于Pubmed数据库检索的人兽共患病及其病原微生物研究现状与趋势分析 |
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| 引用本文： | 基于Pubmed数据库检索的人兽共患病及其病原微生物研究现状与趋势分析.基于Pubmed数据库检索的人兽共患病及其病原微生物研究现状与趋势分析[J].畜牧与饲料科学,2022,43(4):109-115. |
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| 作者姓名： | 基于Pubmed数据库检索的人兽共患病及其病原微生物研究现状与趋势分析 |
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| 作者单位： | 苏州市药品检验检测研究中心,江苏 苏州 215104 |
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| 摘 要： | 目的 获得全球范围内人兽共患病及其病原微生物研究现状和热点变化趋势信息,为我国人兽共患病的防控提供参考。方法 利用COOC 12.6和Citespace 5.8 R1软件对Pubmed数据库中的人兽共患病及其病原微生物相关的关键词进行了频次统计、共现分析、聚类分析、时间线分析和突现词分析。结果 根据Pubmed数据库中 2001—2021年关键词频次统计和共现分析结果,国际关注度较高的人兽共患病及其病原微生物有以下3类:第1类为常见的人兽共患病病原,包括布鲁菌（Brucella）、戊型肝炎病毒（hepatitis E virus）、链球菌（Streptococcus）、大肠杆菌（Escherichia coli）和沙门菌（Salmonella）等,需要持续关注;第2类为近些年在国际上被广泛关注的人兽共患病病原,如新型冠状病毒（SARS-CoV-2）和甲型流感病毒（influenza A virus）等,需要更为深入研究,以尽早控制这些病原的扩散;第3类为在国外特定地区曾大规模出现的人兽共患病,如Q热（Q fever）和中东呼吸综合征（middle east respiratory syndrome,MERS）等,应当重点关注其输入性风险,避免这些疾病在我国暴发。除疾病和病原微生物外,与检测和诊断相关的关键词,如系统发育（phylogeny）和聚合酶链式反应（PCR）等关键词的关注度也较高。聚类分析生成了10个聚类,蜱媒传染病大类提示蜱虫在人兽共患病传播中的作用。时间线和突现词分析结果显示,在病原微生物中,对甲型流感病毒以及新型冠状病毒等的关注度还在逐渐增加。同时,病原微生物检测技术正在从特定序列检测向全基因组学检测技术发展,这些领域极有可能是今后的研究方向和趋势。结论 结果提示,人们对人兽共患病及其病原微生物研究的关注度越来越高,人兽共患病病原微生物检测技术正在发生更新和迭代。我国应重点关注甲型流感以及新型冠状病毒肺炎等疾病的防控,并适当关注蜱媒传染病。这些信息的获取可为我国的人兽共患病的防控提供参考。
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| 关 键 词： | 人兽共患病 病原微生物 PubMed数据库 甲型流感 新型冠状病毒肺炎 全基因组测序 |
Research Status and Trend of Zoonosis and Zoonotic Microorganisms Based on PubMed Database Retrieval |
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| CHEN Li,GU Xiao-hong,JI Wen-jun,PAN Er-zhuo.Research Status and Trend of Zoonosis and Zoonotic Microorganisms Based on PubMed Database Retrieval[J].Animal Husbandry and Feed Science,2022,43(4):109-115. |
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| Authors: | CHEN Li GU Xiao-hong JI Wen-jun PAN Er-zhuo |
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| Institution: | Suzhou Institute for Drug Control,Suzhou 215104,China |
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| Abstract: | Objective] To gather information on the research status and the hot spots of zoonosis and zoonotic microorganisms worldwide, and to provide references for the prevention and control of zoonotic diseases in China. Method] COOC 12.6 and Citespace 5.8 R1 software were used to carry out frequency statistics, co-occurrence analysis, cluster analysis, timeline analysis and burst analysis on the keywords associated with zoonosis and zoonotic microorganisms in PubMed database. Result] According to the keywords frequency statistics and co-occurrence analysis results from the year of 2001 to 2021 in pubMed database, the zoonosis and zoonotic microorganisms arousing high international attentions were classified into the following three categories: the first category was commonly observed zoonotic microorganisms such as Brucella, hepatitis E virus, Streptococcus, Escherichia coli （E. coli） and Salmonella, to which continuous public attentions were still needed to be paid; the second category was the zoonotic microorganisms worldwide concerned in recent years such as severe acute respiratory syndrome coronavirus-2 （SARS-CoV-2） and influenza A virus, which were worthy of more in-depth research to control the spread of these diseases as soon as possible; the third category was the zoonosis that had massively prevailed in specific regions abroad such as Q fever and middle east respiratory syndrome （MERS）, and these diseases were expected to be noticed in terms of imported risks to avoid their outbreaks in China. In addition to the above mentioned zoonosis and zoonotic microorganisms, some keywords associated with detection and diagnosis such as phylogeny and PCR were also of high interests. The cluster analysis generated a total of 10 clusters, in which the tick-borne infectious disease cluster suggested the role of ticks in the transmission of zoonotic diseases; the results of timeline and burst analysis demonstrated that among the zoonotic microorganisms, the attentions being paid to influenza A virus and SARS-CoV-2 were gradually increasing. At the same time, the detection technology of zoonotic microorganisms was evolving from specific sequence detection to whole genome sequencing. These fields were likely to be the research direction and trend in the future. Conclusion] The findings in this study imply that interests in the studies on zoonosis and zoonotic microorganisms are growing, and that advances have being made in the technology used to detect these zoonotic microorganisms. In China, the prevention and control of influenza A and corona virus disease 2019 （COVID-19） should be given top priority and tick-borne infectious diseases should also receive certain attention. These information may serve as a guide for the prevention and control of zoonosis in China. |
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| Keywords: | zoonosis pathogenic microorganisms PubMed database influenza A corona virus disease 2019 whole genome sequencing |
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