| 含三氮唑环和噻吩环希夫碱的合成及其杀菌活性 |
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| 引用本文： | 张欣,覃章兰,肖蒙.含三氮唑环和噻吩环希夫碱的合成及其杀菌活性[J].农药学学报,2005,7(4):353-356. |
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| 作者姓名： | 张欣 覃章兰 肖蒙 |
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| 作者单位： | 华中师范大学,化学学院,湖北,武汉,430079;华中师范大学,化学学院,湖北,武汉,430079;华中师范大学,化学学院,湖北,武汉,430079 |
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| 基金项目： | 湖北省科技攻关项目（2003AA3010B08）. |
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| 摘 要： | 为了设计合成具有更高生物活性的化合物,以3-芳基-4-氨基-5-巯基-1,2,4-三唑与α-噻吩甲醛反应,通过微波法和传统方法设计合成了10个含1,2,4-三唑和噻吩环的希夫碱类化合物,其结构经IR、1H NMR、MS和元素分析确证。对两种方法的优缺点进行了比较。同时对6种病原菌进行了生物活性测试,结果发现,在50 mg/L下,化合物 IIe、IIf 对6种病菌的抑制率大于62%。所有目标化合物对苹果轮纹病菌Dochiorella gregaria和水稻纹枯病菌Rhizatonia solani的抑制率均大于85%。
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| 关 键 词： | 希夫碱 三氮唑 噻吩 杀菌活性 |
| 文章编号： | 1008-7303（2005）04-0353-04 |
| 收稿时间： | 2005-06-22 |
| 修稿时间： | 2005-08-30 |
Synthesis and Fungicidal Activity of Schiff Base of Triazole and Thiophene |
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| ZHANG Xin,QIN Zhang-lan and XIAO Meng.Synthesis and Fungicidal Activity of Schiff Base of Triazole and Thiophene[J].Chinese Journal of Pesticide Science,2005,7(4):353-356. |
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| Authors: | ZHANG Xin QIN Zhang-lan and XIAO Meng |
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| Institution: | 1.Department of Chemistry, Central China Normal University, Wuhan 430079, China |
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| Abstract: | In order to synthesis some compounds with better fungicidal activity, the reaction of 3-aryl-4-amino-5-mercapto-1,2,4-S-triazoles with α-thiophaldehyde in the presence of absolute actonitrile were investigated and ten Schiff bases of triazole and thiophene were obtained by microwave method and traditional method in comparison. Their structures were comfirmed by elemental analysis,IR, 1H NMR and MS. The results to six kinds of pathogenic species of the biological test showed that the compounds IIe and IIf had good inhibitory activities (inhibition rate≥62%) and all of the compounds showed good inhibitory activities (inhibition rate≥85%) to Dothiorella gregaria and Rhizoctonia solani at 50 mg/L. |
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| Keywords: | Schiff base triazole thiophene fungicidal activity |
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