| 禽网状内皮组织增生症流行现状及检测技术研究进展 |
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| 引用本文： | 邓小芸,祁小乐,高玉龙,高宏雷,秦立廷,王永强,王笑梅.禽网状内皮组织增生症流行现状及检测技术研究进展[J].动物医学进展,2010,31(9). |
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| 作者姓名： | 邓小芸 祁小乐 高玉龙 高宏雷 秦立廷 王永强 王笑梅 |
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| 作者单位： | 1. 中国农业科学院哈尔滨兽医研究所,兽医生物技术国家重点实验室,禽传染病研究室,黑龙江哈尔滨,150001;东北农业大学动物医学学院,黑龙江哈尔滨,150030;黑龙江畜牧兽医职业学院,黑龙江双城,150111
2. 中国农业科学院哈尔滨兽医研究所,兽医生物技术国家重点实验室,禽传染病研究室,黑龙江哈尔滨,150001 |
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| 基金项目： | 现代农业产业技术体系建设专项基金，公益性行业(农业)科研专项基金 |
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| 摘 要： | 禽网状内皮组织增生症(RE)是禽类一种重要的致瘤性和免疫抑制性疾病。近年来,国内外鸡群中网状内皮组织增生症病毒(REV)流行比较严重;REV与马立克病病毒(MDV)、鸡贫血病病毒(CAV)和J亚群禽白血病病毒(Avianleukosis virus subgroup J,ALV-J)几种免疫抑制性病毒的混合感染在我国部分养鸡场中均普遍存在,使得鸡群处于免疫力低下的状态,导致禽流感、新城疫等重要疫苗免疫失败,并容易造成继发感染,使疫病的诊断和防控难度加大。另外,REV可以整合到MDV和鸡痘病毒(Fowlpox virus,FPV)基因组中,从而导致商品化疫苗受到污染,并可用做将外源基因插入到鸡和哺乳动物细胞内的表达载体;基于REV传统检测方法的基础上,新型的分子生物学检测技术如PCR、实时荧光PCR、LAMP提高了诊断REV的敏感性和特异性。
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| 关 键 词： | 禽网状内皮组织增生症 流行 感染 基因重组 检测技术 |
Progress on Epidemiology and Detection Technique of Reticuloendotheliosis |
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| DENG Xiao-yun,QI Xiao-le,GAO Yu-long,GAO Hong-lei,QIN Li-ting,WANG Yong-qiang,WANG Xiao-mei.Progress on Epidemiology and Detection Technique of Reticuloendotheliosis[J].Progress In Veterinary Medicine,2010,31(9). |
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| Authors: | DENG Xiao-yun QI Xiao-le GAO Yu-long GAO Hong-lei QIN Li-ting WANG Yong-qiang WANG Xiao-mei |
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| Institution: | DENG Xiao-yun1,2,3,QI Xiao-le1,GAO Yu-long1,GAO Hong-lei1,QIN Li-ting1,WANG Yong-qiang1,WANG Xiao-mei1(1.Division of Avian Infectious Diseases,State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute of CAAS,Harbin,Heilongjiang,150001,China,2.College of Veterinary Medicine,Northeast Agricultural University,150030,3.Vocational College of HeiLongjiang Animal Husbandry and Veterinary Science,Shuangcheng,150111,China) |
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| Abstract: | Reticuloendotheliosis is an oncogenic and immunosuppressive disease for avian.Recently,REV is prevailing in avian in the world.Mixed infections with MDV,CAV and ALV-J exist in poultry in our country,which make chicken hypoimmunity and immune failure after injecting AIV and NDV vaccines,and may cause secondary infection.So it is very difficult to diagnose and control REV.Otherwise,REV can integrate into the Marek's disease virus(MDV) and fowl poxvirus(FPV) genome,which contaminate commercial vaccines and it ... |
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| Keywords: | Reticuloendotheliosis epidemiology infection genome recombination detection technique |
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