| 人参皂苷Rg1对人黑素细胞株MV3黑素合成的影响 |
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| 引用本文： | 赵保胜,徐暾海,郭德海.人参皂苷Rg1对人黑素细胞株MV3黑素合成的影响[J].人参研究,2011(2):9-11. |
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| 作者姓名： | 赵保胜 徐暾海 郭德海 |
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| 作者单位： | 1. 北京中医药大学中药学院·北京北京·100102
2. 中国中医科学院西苑医院·北京北京·100000 |
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| 摘 要： | 目的:观察人参皂苷Rg1对体外培养的人黑素细胞MV3增殖、黑素合成的影响。方法:体外培养黑素细胞,给予不同浓度人参皂苷Rg1(80、40、20、10、5、2.5μg/mL)处理48h后,四甲基偶氮唑蓝法(MTT)观察人参皂苷Rg1对细胞增殖的影响,比色法测定黑素含量变化情况。结果:人参皂苷Rg1 80~10μg/mL剂量能抑制黑素细胞增殖(P<0.01),减少黑素合成(P<0.01或P<0.05),2.5μg/mL剂量则促进黑素细胞增殖,但对黑素合成作用不明显。结论:人参皂苷Rg1可抑制黑素细胞增殖,减少黑素合成,这可能是其具有美白作用的机制之一。
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| 关 键 词： | 人参皂苷人参皂苷Rg1 黑素细胞 黑素 |
The effects of ginsenoside Rg_1 to melanine synthesis on human melanocyte cell line MV3 |
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| Authors: | Zhao Baosheng Xu Tunhai |
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| Institution: | Zhao Baosheng Xu Tunhai(Beijing University of Chinese Medicine,Beijing,100102 China) |
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| Abstract: | Objective： To investigate the effect of ginsenoside Rgl to melanine synthesis on human melanocyte cell line MV3. Methods： Cultured the MV3 cells and administrated with ginsenoside Rg1, the concentrations were 80.40.20.10.5 and 2.5 μg/mL respectively, 48 hours later, observed the influence of ginsenoside Rg, to the MV3 cell proliferation with methyl thiazolyl tetrazolium （MTr） method, and evaluated the change of melanine content with colorimetric method. Results： At 80-10 μg/mL concentration, ginsenoside Rgl inhibited the proliferation of MV3 cells, and decreased the synthesis of melanine, on the contrary, 2.5 μg/mL concentration of ginsenoside Rg1 stimulated the proliferation of MV3 cells, but the increasing of melanine synthesis was blunt. Conlustion： Ginsenoside Rg1 inhibited the proliferation of MV3 ceils and decreased the synthesis of melanine, these may be one of its mechanisms on whiteninz effect. |
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| Keywords: | Ginsenoside Rg1 melanocyte melanine |
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