Protection of the Reproductive Tract of Young Chicks by Newcastle Disease Virus-induced Haemagglutinationinhibition Antibodies |
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| Authors: | J Raghul G Dhinakar Raj B Murali Manohar C Balachandran |
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| Institution: | (1) Department of Veterinary Pathology, Chennai, 600 007, India;(2) Department of Animal Biotechnology, Chennai, 600 007, India;(3) Centralized Clinical Laboratory, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, 600 007, India |
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| Abstract: | The present study was conducted to assess the haemagglutination-inhibition (HI) titres required to protect the chicken reproductive
tract against direct damage caused by Newcastle disease virus (NDV). Precociously induced oviduct and uterus by oestrogen
treatment of young chicks were used to assess the damage or protection against the damage by analysis of ciliostasis or histopathological
lesions. Unvaccinated day-old female white leghorn chickens were used as the maternally derived antibody (MDA) group. Chickens
were vaccinated with either a live lentogenic vaccine on day 14 of age or, along with it, an inactivated vaccine at day 36
of age, to generate birds with a range of primary or secondary response induced HI antibodies. Birds with different HI antibody
levels were challenged with virulent NDV. It was found that a HI antibody titre of 128 and above was protective against direct
damage of the reproductive tract, while the 32–64 titre range was protective when derived through secondary vaccination only. |
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| Keywords: | precocious oviducts protection haemagglutination-inhibition titres |
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