Microinjection of a conserved peptide sequence of p34cdc2 induces a Ca2+ transient in oocytes |
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| Authors: | A Picard J C Cavadore P Lory J C Bernengo C Ojeda M Dorée |
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| Institution: | CNRS and INSERM, Montpellier, France. |
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| Abstract: | The product of the yeast cell cycle control gene cdc2, and its homologs in higher eukaryotes (p34cdc2), all contain a perfectly conserved sequence of 16 amino acids that has not been found in any other protein sequence. Microinjection of this peptide triggers a specific increase in the concentration of intracellular free Ca2+ that originates from intracellular stores in both starfish and Xenopus oocytes. Thus, p34cdc2 might interact through its conserved peptide domain with some component of the Ca2(+)-regulatory system. |
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