Protective role of murine norovirus against Pseudomonas aeruginosa acute pneumonia |
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| Authors: | Marion Thépaut Teddy Grandjean Didier Hober Pierre-Emmanuel Lobert Perrine Bortolotti Karine Faure Rodrigue Dessein Eric Kipnis Benoit Guery |
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| Institution: | .EA 7366: Pseudomonas aeruginosa Host-Pathogen Translational Research Group, UDSL, Université Lille Nord de France, 59045 Lille, France ;.Laboratoire de virologie EA3610, Faculté de Médecine, CHRU, Université Lille 2, 59037 Lille, France |
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| Abstract: | The murine norovirus (MNV) is a recently discovered mouse pathogen, representing the most common contaminant in laboratory mouse colonies. Nevertheless, the effects of MNV infection on biomedical research are still unclear. We tested the hypothesis that MNV infection could alter immune response in mice with acute lung infection. Here we report that co-infection with MNV increases survival of mice with Pseudomonas aeruginosa acute lung injury and decreases in vivo production of pro-inflammatory cytokines. Our results suggest that MNV infection can deeply modify the parameters studied in conventional models of infection and lead to false conclusions in experimental models. |
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