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Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs |
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| Authors: | Tomohiro Osaki Seiji Kurozumi Kimihiko Sato Taro Terashi Kazuo Azuma Yusuke Murahata Takeshi Tsuka Norihiko Ito Tomohiro Imagawa Saburo Minami Yoshiharu Okamoto |
| Institution: | 1.Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan; E-Mails: (K.A.); (Y.M.); (T.T.); (N.I.); (T.I.); (S.M.); (Y.O.);2.Koyo Chemical Co. Ltd., 1-17 Taiyuji-cho, Kita-ku, Osaka 530-0051, Japan; E-Mails: (S.K.); (K.S.); (T.T.) |
| Abstract: | N-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid metabolism after oral GlcNAc administration in dogs. Results showed that plasma levels of ectoine were significantly higher after oral administration of GlcNAc than prior to administration (p < 0.001). To our knowledge, there have been no reports of increased ectoine concentrations in the plasma. The mechanism by which GlcNAc administration leads to increased ectoine plasma concentration remains unclear; future studies are required to clarify this mechanism. |
| Keywords: | amino acid cartilage regeneration dog N-acetyl-d-glucosamine hydrochloride TGF-beta |