| Abstract: | The plasma levels of chloramphenicol were determined following i.m. administration in three groups of water buffalo (n= 4 per group). The absorption of chloramphenicol was relatively rapid since concentrations of 7.00 ± 0.62 μg/ml were detected in plasma after 1 h and peak concentrations of 9.25 ± 0.53 μg/ml were obtained 3 h following administration of 30 mg/kg. A concentration of at least 5 μg/ml was achieved at the end of 1 h and persisted up to 12 h (6.79 ± 1.19 μg/ml). With repetition of 10 and 20 mg/kg dose at 12 h, concentrations greater than 5 μg/ml persisted for an additional 8 and 12 h, respectively. The distribution studies of chloramphenicol in tissues and body fluids at 4 h post-injection (30 mg/kg i.m., n= 4, group IV), revealed that the highest concentration was seen in bile (31.67 ± 6.21 μg/ml), followed by liver, kidney, plasma, heart, skeletal muscle and brain (4.00 ± 0.50 μg/g). |
