| 呋喃唑酮代谢物AOZ在斑点叉尾(鲴)体内组织分布与消除规律研究 |
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| 引用本文： | 刘永涛,艾晓辉,索纹纹,余少梅,杨秋红.呋喃唑酮代谢物AOZ在斑点叉尾(鲴)体内组织分布与消除规律研究[J].淡水渔业,2012(5):38-44. |
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| 作者姓名： | 刘永涛 艾晓辉 索纹纹 余少梅 杨秋红 |
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| 作者单位： | 中国水产科学研究院淡水研究中心;中国水产科学研究院长江水产研究所农业部淡水鱼类种质监督检验测试中心;华中农业大学水产学院 |
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| 基金项目： | 中央及公益性研究院所基本科研业务费专项资金资助项目(2011JBFA19);公益性行业(农业)科研专项经费(201203085) |
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| 摘 要： | 研究了在池塘网箱养殖模式下,平均水温为30.6℃,以100 mg/kg鱼体重的剂量投饲斑点叉尾鲴(Ietalurus punetaus)苗种(95±20.9)g含呋喃唑酮的药饵,连续5d,每天2次.采用高效液相色谱串联质谱(HPLC-ESI/MS/MS)法分析了呋喃唑酮主要代谢产物3-氨基-2-噁唑烷酮(3-amina...
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| 关 键 词： | 斑点叉尾(鲴)(Ietalurus punetaus) 呋喃唑酮 3-氨基-2-噁唑烷酮 组织分布 消除 |
Tissue distribution and elimination rules of the metabolite(AOZ) of Furazolidone residues inIetalurus punetaus |
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| LIU Yong-tao,AI Xiao-hui,SUO Wen-wen,YU Shao-mei,YANG Qiu-hong.Tissue distribution and elimination rules of the metabolite(AOZ) of Furazolidone residues inIetalurus punetaus[J].Freshwater Fisheries,2012(5):38-44. |
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| Authors: | LIU Yong-tao AI Xiao-hui SUO Wen-wen YU Shao-mei YANG Qiu-hong |
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| Institution: | 1,2 (1.Freshwater Fisheries Research Center,Chinese Academy of Fishery Science,Wuxi,Jiangsu 214081,China; 2.Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Science/Freshwater Fish Germplasm Quality Supervision and Testing Center,Ministry of Agriculture,Wuhan 430223,China; 3.College of Fisheries,Huazhong Agricultural university,Wuhan 430070,China) |
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| Abstract: | Tissue distribution and elimination rules of furazolidone metabolite 3-amina-2-oxazolidinone(AOZ) was studied in channel catfish cultured in the cages of pond at the average temperature was 30.6 ℃ during the whole experiment.Channel catfish were continuously fed feed containing furazolidone twice everyday for 5 days at the dose of 100 mg/kg fish body weight.The concentrations of AOZ in blood and tissues(muscle,skin,liver,and kidney) were detected by liquid chromatography tandem mass spectrometric(HPLC-ESI/MS/MS).The concentrations of AOZ were(2 649.0±463.1)ng/mL,(1 169.4±194.5),(2 308.5±100.5),(7 816.2±568.5) and 15 938.1 μg/kg in blood,muscle,skin,liver,and kidney respectively after drug withdrawal for 4 hours.Average concentrations of AOZ in blood,muscle,skin,liver,and kidney were 6.66 ng/mL,4.50,33.7,17.1,21.3 μg/kg respectively on the 60th day and were 6.66,4.50,33.7,17.1,21.3 times of 1 μg/kg which was the determination limit of AOZ.AOZ was not detected on the 90th day in blood and all kinds of tissues.The concentration levels of AOZ from high to low in tissues were kidney,liver,skin,blood,and muscle.The elimination half-life T1/2(d) were 11.1 d(skin),7.8 d(muscle),7.2 d(blood),6.9 d(liver),and 6.7 d(kidney).The concentration of AOZ in skin was higher than in muscle and residue time was longer.In this cultured conditions,the elimination period of AOZ' in channel catfish tissues was 2754 ℃·d. |
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| Keywords: | Ietalurus punetaus furazolidone 3-amina-2-oxazolidinone(AOZ) tissue distribution elimination |
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