Evaluation of in vitro and in vivo inhibitory effects of fusidic acid on Babesia and Theileria parasites |
| |
| Authors: | Akram Ahmed Salama Mahmoud AbouLaila Ahmed A Moussa Mohamed A Nayel Ahmed El-Sify Mohamad A Terkawi Hany Y Hassan Naoaki Yokoyama Ikuo Igarashi |
| |
| Institution: | 1. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido 080-8555, Japan;2. Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Minoufiya University, Sadat City, Minoufiya, Egypt;3. Department of Parasitology, Faculty of Veterinary Medicine, Minoufiya University, Sadat City, Minoufiya, Egypt;4. Department of Biochemistry, Faculty of Veterinary Medicine, Minoufiya University, Sadat City, Minoufiya, Egypt |
| |
| Abstract: | Fusidic acid known to has antibacterial, antifungal, and antimalarial activities. Fusidic acid blocks translation elongation factor G gene in Plasmodium falciparum. In the present study, the inhibitory effects of fusidic acid on the in vitro growth of bovine and equine Babesia parasites were evaluated. The inhibitory effect of fusidic acid on the in vivo growth of Babesia microti was also assessed. The in vitro growth of four Babesia species that were tested was significantly inhibited (P < 0.05) by micromolar concentrations of fusidic acid (IC50 values = 144.8, 17.3, 33.3, and 56.25 μM for Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi, respectively). Combinations of fusidic acid with diminazene aceturate synergistically potentiated its inhibitory effects in vitro on B. bovis and B. caballi. In B. microti-infected mice, fusidic acid caused significant (P < 0.05) inhibition of the growth of B. microti at the dose of 500 mg/kg BW relative to control group. These results indicate that fusidic acid might be incorporated in treatment of babesiosis. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
