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| 氟苯尼考双混悬型乳剂对猪沙门氏菌病的疗效试验 | |
| 引用本文： | 李孝文,章洪皲,罗小峰,戴霞亮,潘杜娟,梅金健,刘小凤,孙志良.氟苯尼考双混悬型乳剂对猪沙门氏菌病的疗效试验[J].中国动物保健,2012(6):19-22. |
| 作者姓名： | 李孝文 章洪皲 罗小峰 戴霞亮 潘杜娟 梅金健 刘小凤 孙志良 |
| 作者单位： | 1. 武汉天种畜牧有限公司湖北武汉430344 2. 湖南农业大学动物医学院湖南长沙410128 3. 国家生猪产业体系黄陂综合试验站湖北武汉430344 4. 湖南省兽药工程技术研究中心湖南长沙410311 |
| 基金项目： | 国家生猪产业体系项目基金(CARS-36-02A、CARS-36-06B、CARS-36-07B);湖南省科技重大专项(2009FJ1005) |
| 摘 要： | 为了研究氟苯尼考双混悬型乳剂的临床治疗效果,确定该新制剂的治疗剂量及使用间隔时间,建立体重为12±1.5kg的大约克小肥猪沙门氏菌人工感染病理模型,以氟苯尼考注射液为对照组,肌肉注射氟苯尼考双混悬型乳剂高(30mg/kg·bw)、中(20mg/kg·bw)和低(10mg/kg·bw)剂量组开展临床治疗与观察。结果所有试验组治疗率均在70%以上,高剂量组显著高于低剂量组和药物对照组(p<0.05),中剂量组显著高于药物对照组(p<0.05)。因此,氟苯尼考双混悬型乳剂中剂量组(20mg/kg·bw)3d给药1次,连续2次可以达到良好的治疗效果。 |
| 关 键 词： | 氟苯尼考双混悬型乳剂 人工感染 沙门氏菌病 临床疗效 |
The Clinical Trial of Dual Suspension Emulsion of Florfenicol Against Artificial Contagious Swine Salmonellosis |
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| Li Xiaowen,Zhang Hongjun,Luo Xiaofeng,Dai Xialiang,Pan Dujuan,Mei Jinjian,Liu Xiaofeng,Sun Zhiliang.The Clinical Trial of Dual Suspension Emulsion of Florfenicol Against Artificial Contagious Swine Salmonellosis[J].China Animal Health,2012(6):19-22. | |
| Authors: | Li Xiaowen Zhang Hongjun Luo Xiaofeng Dai Xialiang Pan Dujuan Mei Jinjian Liu Xiaofeng Sun Zhiliang |
| Institution: | 1 (1. Wuhan Tianzhong Husbandry Co. , Ltd, Wuhan Hubei, 430344; 2. College of Veterinary medicine, Hunan Agricultural University, Changsha Hunan, 410128 ; 3.National Swine Industry Technology System of Huangpi Experimental Station, Wuhan Hubei, 430344; 4.Hunan Engineering Research Center of Veterinary Drugs, Changsha Hunan, 410128) |
| Abstract: | In order to explore the clinical therapeutic effect of Dual Suspension Emulsion of Florfenicol(DSEF) and determine the medication regimen, The swine Salmonella artificial infection model of Yorkshire castrated pigs of 12±1.5kg body weight was established. The Florfenicol Injection(FI) was used as the control group and the high ( 30mg / kg·bw ), ( 20mg / kg·bw ) and low dose ( 10mg / kg·bw ) group of DSEF were used for clinical treatment and observation.The results show that the treatment rates of all the test group were 70% above ; high dose group was higher than that in low dose group and drug control group (P < 0.05) and middle dose group was higher than that in drug control group (P < 0.05). Therefore, the medication regimen of DSEF for middle dose group (20mg/kg·bw) 3d/times and 2 times in a row was a good treatment. |
| Keywords: | Dual Suspension Emulsion of Florfenicol artificial infection Salmonellosis clinical efficacy |
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