| 1例猫肾上腺皮质癌脾转移的病理及免疫组化分析 |
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| 引用本文： | 邓朝阳,王峥,张佳韧,何希君,郑家三.1例猫肾上腺皮质癌脾转移的病理及免疫组化分析[J].畜牧兽医学报,2021,52(12):3669-3674. |
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| 作者姓名： | 邓朝阳 王峥 张佳韧 何希君 郑家三 |
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| 作者单位： | 1. 黑龙江八一农垦大学动物科技学院, 大庆 163319;2. 中国农业科学院哈尔滨兽医研究所 兽医生物技术国家重点实验室, 哈尔滨 150069 |
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| 基金项目： | 国家重点研究发展计划（2016YFD0501008）；黑龙江八一农垦大学三横三纵支持计划（TDJH201903） |
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| 摘 要： | 猫的肾上腺皮质癌转移至脾在兽医临床非常罕见。在本报告中，描述了1例10岁田园猫，其症状表现为腹部疼痛，频繁呕吐，消瘦，有慢性肾上腺功能损伤病史，影像学检查脾肿大。对患猫进行脾摘除手术，并对摘除的组织进行组织病理学检查和免疫组化分析。病理组织学结果显示，肿瘤细胞具有丰富的脂质样空泡，细胞体积大，有丝分裂象多见，且肿瘤细胞已发生血管侵袭，细胞核浓染；免疫组织化学结果显示，synaptophysin、S-100和GATA4阳性表达。根据病理组织学和免疫组织化学及病史和实验室检查，最后诊断为肾上腺皮质癌的脾转移。首次报道了猫肾上腺皮质癌脾转移临床病例及病理学诊断，对于临床相关疾病诊疗有一定的参考价值和借鉴意义。
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| 关 键 词： | 猫 肾上腺皮质癌 病理学 免疫组织化学 |
| 收稿时间： | 2021-03-19 |
Pathological and Immunohistochemical Analysis of Splenic Metastasis of Adrenal Cortical Carcinoma in a Cat |
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| DENG Zhaoyang,WANG Zheng,ZHANG Jiaren,HE Xijun,ZHENG Jiasan.Pathological and Immunohistochemical Analysis of Splenic Metastasis of Adrenal Cortical Carcinoma in a Cat[J].Acta Veterinaria et Zootechnica Sinica,2021,52(12):3669-3674. |
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| Authors: | DENG Zhaoyang WANG Zheng ZHANG Jiaren HE Xijun ZHENG Jiasan |
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| Institution: | 1. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China;2. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China |
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| Abstract: | Metastasis of adrenal cortical carcinoma to the spleen in cats is very rare in veterinary clinical cases. In this report, a 10-year-old farm cat with abdominal pain, frequent vomiting, wasting, a history of chronic adrenal impairment, and splenomegaly on radiographic examination was described. Spleneectomy was performed on the cat and histopathological examination of the removed tissue was performed. Histopathological results showed that the tumor cells had abundant lipid-like vacuoles, large cell volume, and many mitotic images. The tumor cells had vascular invasion, and the nucleus was heavily stained. Immunohistochemical results showed positive expression of synaptophysin, S-100 and GATA4. Based on histopathology and immunohistochemistry, history and laboratory examination, the final diagnosis was splenic metastasis of adrenal cortical carcinoma. The clinical case and pathological diagnosis of splenic metastasis of adrenal cortical carcinoma in cats were reported for the first time, which has certain reference value for the clinical diagnosis and treatment of related diseases. |
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| Keywords: | cat adrenocortical carcinoma histopathology immunohistochemistry |
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