| 拷贝数变异在家禽育种中的研究进展 |
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| 引用本文： | 张易,白皓,毕瑜林,路奥,黄艳丽,陈国宏,常国斌.拷贝数变异在家禽育种中的研究进展[J].畜牧兽医学报,2020,51(11):2633-2640. |
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| 作者姓名： | 张易 白皓 毕瑜林 路奥 黄艳丽 陈国宏 常国斌 |
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| 作者单位： | 1. 扬州大学动物科学与技术学院, 扬州 225009;2. 扬州大学农业科技发展研究院, 教育部农业与农产品安全国际合作联合实验室, 扬州 225009;3. 扬州大学创新创业学院, 扬州 225009 |
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| 基金项目： | 江苏现代农业（水禽）产业技术体系（JATS[2019]310）；江苏省农业科技自主创新资金项目（CX（18）1004）；扬州大学大学生创新创业训练计划项目（C202011117029Y） |
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| 摘 要： | 拷贝数变异（copy number variation，CNV）是广泛存在于畜禽基因组中的一类重要的遗传变异，通常以大片段的DNA序列缺失或重复形式出现，直接影响着基因表达和功能。CNV与许多遗传疾病和表型性状密切相关，因此引起了广大动物遗传育种工作者的密切关注。本文综述了CNV的形成原因、作用机制、检测方法以及现阶段国内外对家禽CNV的研究进展，并讨论了当前CNV研究工作中存在的问题和困难，旨在为实现CNV作为家禽育种中的分子遗传标记进行辅助育种提供参考。
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| 关 键 词： | 拷贝数变异 基因组 家禽育种 |
| 收稿时间： | 2020-04-14 |
Research Progress of Copy Number Variation in Poultry Breeding |
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| ZHANG Yi,BAI Hao,BI Yulin,LU Ao,HUANG Yanli,CHEN Guohong,CHANG Guobin.Research Progress of Copy Number Variation in Poultry Breeding[J].Acta Veterinaria et Zootechnica Sinica,2020,51(11):2633-2640. |
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| Authors: | ZHANG Yi BAI Hao BI Yulin LU Ao HUANG Yanli CHEN Guohong CHANG Guobin |
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| Institution: | 1. College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China;2. Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Institute of Agricultural Science and Technology Development, Yangzhou University, Yangzhou 225009, China;3. College of Innovation and Entrepreneurship, Yangzhou University, Yangzhou 225009, China |
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| Abstract: | Copy number variation (CNV) is an important type of genetic variation which widely exists in livestock and poultry genomes. It usually occurs in the form of deletion or duplication of large DNA sequences, which directly affects gene expression and function. CNV is closely related to many genetic diseases and phenotypic traits, and therefore has attracted close attention of animal genetics and breeding workers. The formation causes, action mechanism, detection methods, and the research progress of CNV in poultry were summarized in this article, and the difficulties and problems in current CNV studies were discussed, which aims to provide a reference for the realization of CNV as a molecular genetic marker in poultry for assisted breeding. |
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| Keywords: | copy number variation genome poultry breeding |
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