Kinetics of immune response to foot-and-mouth disease virus (type Asia 1) in experimental cattle |
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| Authors: | M S Mohan M R Gajendragad Subodh Kishore S Gopalakrishna Nem Singh |
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| Institution: | (1) Indian Veterinary Research Institute, Bangalore, 560024 Karnataka, India;(2) Project Directorate on Animal Disease Monitoring and Surveillance, Hebbal, Bangalore, 560024 Karnataka, India;(3) Joint Directorate of Research, Indian Veterinary Research Institute, Izatnagar, 234143, UP, India |
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| Abstract: | Humoral and mucosal (secretory antibody)immune response to FMDV type Asia 1 in cattle was analyzed after vaccination and infection
using virus neutralizing test (VNT). Vaccination (1/16th the usual dose) failed to protect cattle from generalized clinical
disease following experimental FMDV Asia 1 infection. Our results showed that infection induced higher and prolonged serum
antibody titres indicating antigen mass is important for optimal immune response. Experimental FMDV infection induced significant
secretory antibody (mucosal) response in cattle. Though, there was no difference in the serum antibody response between the
cattle that developed generalized infection (unprotected) and those with only localized infection (protected), secretory antibody
response differed, wherein the unprotected cattle had higher secretory response than protected cattle. Thus, FMDV Asia 1 infection
stimulates a similar serum antibody response and a unique secretory antibody response among the infected cattle.
An erratum to this article can be found at |
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| Keywords: | Cattle FMDV Humoral immune response Mucosal immune response Neutralizing antibody titres Secretory antibody response Serum antibody response |
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