| 蜜环菌多糖对损伤性胰岛细胞分泌功能的影响 |
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| 引用本文： | 操玉平,于敏,沈业寿,陆军,许宝奎.蜜环菌多糖对损伤性胰岛细胞分泌功能的影响[J].中国食用菌,2009,28(1). |
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| 作者姓名： | 操玉平 于敏 沈业寿 陆军 许宝奎 |
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| 作者单位： | 安徽大学生命科学学院安徽大学中药研究与开发重点实验室,安徽,合肥,230039 |
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| 基金项目： | 国家自然科学基金，安徽省教育厅自然科学基金 |
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| 摘 要： | 培养大鼠胰岛素瘤细胞(INS-1),以四氧嘧啶(AXN)损伤细胞,培养液中加入不同浓度的多糖AMP-1,检测不同浓度AMP-1对INS-1细胞葡萄糖刺激的胰岛素和C肽分泌量的影响,同时检测细胞存活率。结果表明,一定浓度范围AMP-1对AXN损伤的INS-1细胞分泌胰岛素和C肽均具有一定的促进作用,尤其是在葡萄糖刺激浓度为16.7mmol·L-1时,效果显著;AMP-1可减少AXN对INS-1细胞的损伤,使INS-1细胞存活率增加。
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| 关 键 词： | 蜜环菌 菌索多糖 四氧嘧啶 胰岛素瘤细胞 胰岛素 C肽 |
The Effect of Polysaccharides from Armillariella mellea (AMP-1) on Injured INS-1 Cells |
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| CAO Yu-ping,YU Min,SHEN Ye-shou,LU Jun,XU Bao-kui.The Effect of Polysaccharides from Armillariella mellea (AMP-1) on Injured INS-1 Cells[J].Edible Fungi of China,2009,28(1). |
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| Authors: | CAO Yu-ping YU Min SHEN Ye-shou LU Jun XU Bao-kui |
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| Institution: | CAO Yu-ping; YU Min; SHEN Ye-shou; LU Jun; XU Bao-kui (School of Life Science of Anhui University; The Key Lab of Chinese Traditional Medicine Research and Development of Anhui University; Hefei Anhui 230039); |
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| Abstract: | Graded concentrations of AMP-1 were added into the culture medium of INS-1 cells injured by alloxan. The amount of glucose-stimulated insulin and C-peptide secretions in different concentration of AMP-1 was determined and the survival rate was measured. The results showed that graded concentrations of AMP-1 could promote glucose-stimulated insulin and C-peptide secretions in INS-1 cells, especially in the concentration of 16.7 mmol·L -1 of glucose. AMP -1 could reduce the injuries induced by alloxan in INS-... |
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| Keywords: | Armillariella mellea AMP Alloxan INS-1 cells Insulin C-peptide |
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