Dual activation of the Drosophila toll pathway by two pattern recognition receptors |
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| Authors: | Gobert Vanessa Gottar Marie Matskevich Alexey A Rutschmann Sophie Royet Julien Belvin Marcia Hoffmann Jules A Ferrandon Dominique |
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| Institution: | Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg Cedex, France. |
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| Abstract: | The Toll-dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 (GNBP1) gene and leads to compromised survival of mutant flies after Gram-positive infections, but not after fungal or Gram-negative bacterial challenge. Our results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway. The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects. |
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