| “加味白头翁”颗粒剂的制备及稳定性考察 |
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| 引用本文： | 杨璐,王亮,李福杏,殷中琼,王惠,李杨.“加味白头翁”颗粒剂的制备及稳定性考察[J].中国畜牧兽医,2012,39(10):238-241. |
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| 作者姓名： | 杨璐 王亮 李福杏 殷中琼 王惠 李杨 |
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| 作者单位： | 1. 成都农业科技职业学院,四川成都,611130
2. 四川农业大学动物医学院,四川雅安,625014 |
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| 基金项目： | 成都农业科技职业学院重点项目 |
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| 摘 要： | 文章旨在通过颗粒剂制备流程中各辅料种类及其用量的选择、成型工艺和稳定性的考察,确定"加味白头翁"最佳的颗粒剂制备工艺。以软材品质为考察指标,考察药液与总辅料的用量比;采用正交试验,以外观、澄明度、含水量与颗粒质量损失率为综合考察指标对可溶性淀粉用量、α-乳糖用量、糊精用量与羧甲基纤维素钠(HPMC)浓度4因素进行优化研究,确定颗粒的最佳制备工艺。试验结果表明,当辅料与药液比为5∶1时,软材品质良好;当可溶性淀粉∶α-乳糖∶糊精为3∶1∶1时,以0.3％ HPMC作黏合剂,颗粒剂各方面指标最优。通过试验证明,中药复方"加味白头翁"的颗粒剂制备在实验室条件下具有可行性,制备工艺简单明了,所制备颗粒成型好、稳定性高,各方面性质符合药典规定。
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| 关 键 词： | 加味白头翁 颗粒剂 制备 稳定性 |
| 收稿时间： | 2012-05-23 |
Study of Preparation and Stability of ‘Modified Pulsatilla' Granules |
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| YANG Lu
,
WANG Liang
,
LI Fu-xing
,
YIN Zhong-qiong
,
WANG Hui
,
LI Yang.Study of Preparation and Stability of ‘Modified Pulsatilla' Granules[J].China Animal Husbandry & Veterinary Medicine,2012,39(10):238-241. |
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| Authors: | YANG Lu WANG Liang LI Fu-xing YIN Zhong-qiong WANG Hui LI Yang |
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| Institution: | 1. Chengdu Professional College of Agricultural Science and Technology, Chengdu 611130, China;2. College of Veterinary Medicine, Sichuan Agricultural University, Ya’an 625014, China |
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| Abstract: | Through selecting the kinds of adjuvant and its dosage, investigating pharmaceutical technology and stability in granules preparation procedure, the assay was aimend to establish a optimum granules preparation technology of traditional Chinese medicine compound ‘Modified Pulsatilla’. Taking quality of soft material as appraisal indice, investigating the quantity ratio between medicine solution and adjuvant, taking appearance, clear degrees, water content, loss rate of granules quality as appraisal indices to study of the dosage of soluble starch, the dosage of α-lactose, the dosage of dextrin and the concentration of HPMC, and at last to establish a optimum granules preparation technology. When the ratio was 5∶1 between medicine solution and adjuvant, the quality of soft material was good. When the adhesive phase was 0.3% HPMC and the ratio was 3∶1∶1 among soluble starch, α-lactose and dextrin, every appraisal indice of granules was best. Through the test, it was proved that the traditional Chinese medicine compound ‘Modified Pulsatilla’ granules could be preparated in the condition of laboratory. The preparation technology was simple and clear, the granules were forming effective, high stability and up to specification which was in the pharmacopeia of China. |
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| Keywords: | modified pulsatilla granular formulation preparation stability |
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