A Controlled Safety Study of Elevated Dosages of Trimethoprim Plus Sulfadiazine in Mature Horses |
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Authors: | Craig Reinemeyer Robbin Koenig Peggy Anne Hawkins |
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Institution: | 1. East Tennessee Clinical Research, Inc, Rockwood, TN;2. Biotechnical Services, Inc, North Little Rock, AR;3. Aurora Pharmaceutical, LLC, Northfield, MN |
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Abstract: | A novel, proprietary, oral suspension of trimethoprim plus sulfadiazine (TMP/SDZ) had no serious adverse effects on clinical, laboratory, or pathologic parameters of mature horses when administered at up to five times the intended combined dosage of 24 mg/kg twice daily for 30 consecutive days. Loose feces was the most common observation that was likely related to TMP/SDZ treatment, and the incidence of loose feces was greater in groups treated with higher dosages of TMP/SDZ. However, all episodes were self-limiting, and no horses were treated for loose feces. |
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Keywords: | Sulfadiazine Trimethoprim Safety Horse Streptococcus zooepidemicus |
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